jeudi 2 avril 2020

Onco Actu du 2 avril 2020


2.13 ETIOLOGIE - NDMA



Zantac, generics ordered off the market after FDA finds they're a ticking time bomb [Fierce Pharma]











Contamination concerns spur FDA call for nationwide withdrawal of heartburn drug [Biopharma Dive]











FDA Requests Removal of All Ranitidine Products (Zantac) from the Market [FDA]










FDA seeks withdrawal of heartburn drugs due to new carcinogen concerns [EndPoints]











2.5 ETIOLOGIE - GÉNOME



Inherited mutation can predispose children to a type of brain tumor [St. Jude Children's Research Hospital]











4.12 BIOPSIES LIQUIDES



New sensors could offer early detection of lung tumors [MIT]











4.9 DÉP., DIAG. & PRONO. - SEIN



Breast density, microcalcifications, and masses may be heritable traits [EurekAlert!]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Majority of patients responded in CAR T-cell trial for mantle cell lymphoma [MD Anderson Cancer Center]










5.12.4 IMMUNOTHÉRAPIES - ESSAIS



Immunotherapy effective in metastatic prostate cancers with specific markers of immune activation [MD Anderson Cancer Center]











5.12.5 IMMUNOTHÉRAPIES - PHARMA



Merck Announces KEYTRUDA® (pembrolizumab) Significantly Improved Progression-Free Survival as First-Line Treatment for Advanced Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Colorectal Cancer [Merck]











5.12.5.1 IMMUNOTHÉRAPIES - BIOTECH



Phase 3 Clinical Trial of Tedopi®: OSE Immunotherapeutics Announces Positive Top-Line Results for Step-1 of its trial ‘Atalante 1’ in Non-Small Cell Lung Cancer [OSE]











ITeos nabs $125M as they prep Keytruda combination trial — if Covid-19 will let them [EndPoints]











5.12.8 IMMUNOTHÉRAPIES - ECONOMIE



Gilead fails to overturn $752M CAR-T patent verdict. Will BMS win case for larger penalties? [Fierce Pharma]











6.15 LUTTE CONTRE LES CANCERS - COVID-19



Patient Has Virus and Serious Cancer. Should Doctors Withhold Ventilator? [NY Times]










Cancer patients see care disrupted by COVID-19 pandemic [UPI]











6.6 PUBLICATIONS, POLITIQUES SCIENTIFIQUES



Synchronized editing: the future of collaborative writing [Nature]