Onco Actu du 27 mars 2020

	1. BIOLOGIE
Pancreatic cancer cells use the same energy as sprinters’ muscles to spread [Cancer Research UK] It turns out that the pancreatic cancer cells grown in stiffer environments also had higher levels of creatine and an enzyme called creatine kinase B-type (CKB), which turns creatine phosphate into creatine.
	4.7 DÉP., DIAG. & PRONO. - COL DE L'UTÉRUS
Cervicovaginal Microbiomes of HPV-Infected Women Lead To Potential Pre-Cancer Marker [Genome Web] The results, published in PLOS Pathogens on Thursday, suggested that cervical pre-cancer progression coincided with a rise in Gardnerella representation and enhanced microbial diversity.
	5.1 TRAITEMENTS - PRÉ-CLINIQUE
Moffitt Researchers Discover Novel Role of Specific Histone Deacetylase in Non-Small Cell Lung Cancer [Moffitt Cancer Center] In a new article published online in Scientific Reports, they highlight how targeting the histone deacetylase HDAC11 may be a novel therapeutic strategy for NSCLC.
	5.12.5.1 IMMUNOTHÉRAPIES - BIOTECH
VBL and its “gene therapy” cancer treatment are back — with a peek at PhIII potential [EndPoints] VB-111 is what the company deems a “gene therapy agent.” It uses an adenovirus — the viral vector traditionally used for gene therapy — that carries a gene to cause explosive cell death in tumors, rupturing blood cells.
	5.17 TRAITEMENTS - RADIOTHÉRAPIE
Intense Form of Radiation Slows Disease Progression in Some Men with Prostate Cancer That Has Spread [Johns Hopkins] Highly focused, intense doses of radiation called stereotactic ablative radiation (SABR) may slow progression of disease in a subset of men with hormone-sensitive prostate cancers that have spread to a few separate sites in the body, according to results of a phase II clinical trial of the therapy.
	5.3 TRAITEMENTS - FDA, EMA,...
No change to product information for breast cancer medicine Tyverb following re-assessment of data [EMA] The product information for Tyverb, a breast cancer medicine, will continue to state that no data are available on the effectiveness of Tyverb used together with an aromatase inhibitor compared with trastuzumab used with an aromatase inhibitor in patients previously treated with trastuzumab.
	6.15 LUTTE CONTRE LES CANCERS - COVID-19
COVID-19 prompts Pfizer to stop enrollment in most studies [Fierce Biotech] The action sees Pfizer join Bristol Myers Squibb and Eli Lilly on the list of Big Pharma companies to revise their R&D plans in light of the novel SARS-CoV-2 coronavirus.
	6.7.3 DMP
Government rules led electronic health records astray. It’s time to reimagine them [STAT] After 10 years of use and billions of dollars of investment, electronic health records (EHRs) have not only failed to live up to their potential but have helped create a crisis in medicine.