jeudi 6 février 2020

Onco Actu du 6 février 2020


1.1 BIOLOGIE - GÉNOME



First comprehensive survey of virus DNA found within cancer cells [University of East Anglia]











Signs of cancer can appear long before diagnosis, study shows [The Guardian]











Traces of immortality in tumor DNA [DKFZ]











Genomics: data sharing needs an international code of conduct [Nature]










Large-Scale Pan-Cancer Analysis Expands Set of Alterations Disrupting Key Genes, Pathways [Genome Web]











Cancer-causing culprits will be caught by their DNA fingerprints [Sanger Institute]











International collaboration generates most complete cancer genome map to date [Broad Institute]











Landmark study to transform cancer treatment [BBC News]











Global genomics project unravels cancer’s complexity at unprecedented scale [Nature]










Massive cancer genome study reveals how DNA errors drive tumor growth [Science]











Unraveling the story behind the cancers we can’t explain [OICR]











Signs of cancer that occur years before diagnosis could lead to earlier cancer detection [Francis Crick Institute]











Pan-Cancer Analysis of Whole Genomes [Nature]











1.4 BIOLOGIE - TECHNOS, MODÈLES



Step aside CRISPR, RNA editing is taking off [Nature]










DNA Prime Editing: A New CRISPR-Based Method to Correct Most Disease-Causing Mutations [JAMA]











3.1.1 PRÉVENTION - TABAC - E-CIGS



Juul and other e-cig makers to Congress: FDA, not you, should regulate us [STAT]











4.10 DÉP., DIAG. & PRONO. - POUMON



‘Irrefutable evidence’ that lung cancer screening works [Queen Mary University of London]











4.12 BIOPSIES LIQUIDES



Study finds blood test accurately tracks HPV-linked head and neck cancer [UNC]











5.10 TRAITEMENTS - ESSAIS



How AI is making clinical trials more accurate and affordable [Pharmafile]











5.12 IMMUNOTHÉRAPIES



The Contrarian Who Cures Cancers [Quanta]










5.12.11 IMMUNOTHÉRAPIES - PRÉ-CLINIQUE



Researchers develop method to engineer immune cells so they grow even in hostile tumors [UNC]











Targeting the cancer microenvironment [Vienna University]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Invectys reports in vivo efficacy of its pan anti-tumor anti-HLA-G CAR-T cells [Invectys]











CD19 CAR NK-cell therapy achieves 73% response rate in patients with leukemia and lymphoma [MD Anderson Cancer Center]











5.12.5 IMMUNOTHÉRAPIES - PHARMA



Merck Charts an R&D-Focused Course Starting With a $6.5B Spinoff [Xconomy]










Merck preaches the value of ‘focus’ as it spins off $6.5B women’s health, biosimilars units [Fierce Pharma]











Spinning Off [In The Pipeline]











Merck to spin off new $6.5 billion firm focused on women’s health, older drugs [STAT]











It's not just about Keytruda, Merck insists, as it carves out assets worth $6.5B into new company [EndPoints]











Merck to slim down with asset spinoff, focus on Keytruda, vaccines [Reuters]











5.12.8 IMMUNOTHÉRAPIES - ECONOMIE



Kite isn't flying with investors, and Gilead knows it [Biopharma Dive]











5.2.6 PHARMA - BIOTECH



MaaT bags €18M to test microbiome modulators in cancer patients [Fierce Biotech]











French cancer-focused microbiome player is flush with €18M Series B injection [EndPoints]











5.3 TRAITEMENTS - FDA, EMA,...



Everyone’s a Critic: FDA Under Fire for High Drug Approval Numbers [FDA Law Blog]










6.1 OBSERVATION



Adolescent Obesity and Midlife Cancer Risk [ESMO]











6.6 PUBLICATIONS, POLITIQUES SCIENTIFIQUES



Nature will publish peer review reports as a trial [Nature]