mardi 3 décembre 2019

Onco Actu du 3 décembre 2019


1. BIOLOGIE



Single-Cell Analysis Uncovers Regulatory Program in Rare Leukemia [Genome Web]











New principle for activation of cancer genes discovered [Karolinska Institutet]











Researchers at IRB Barcelona study how altered protein degradation contributes to the development of tumours [IRB]











1.1 BIOLOGIE - GÉNOME



A picture is worth a thousand base pairs [Nature]











3.1.1 PRÉVENTION - TABAC - E-CIGS



Massachusetts State Health Department is Completely Irresponsible in Hiding the Cause of Vaping-Associated Respiratory Illness [The Rest of The Story]











4. DÉPISTAGE, DIAGNOSTIC ET PRONOSTIC



Study shows importance of Quality of Life scores as prognostic factors in cancer patients [EORTC]










4.5 DÉP., DIAG. & PRONO. - COLORECTAL



ICO and IDIBELL researchers study the risk of false positives in colon screening during the period 2000-2017 [IDIBELL]











4.9 DÉP., DIAG. & PRONO. - SEIN



ACR, BCRF and GE Healthcare Launch CMIST Trial [ACR]











Developing a new AI breast cancer diagnostic tool [EurekAlert!]











5.10 TRAITEMENTS - ESSAIS



Olaparib becomes first gene-targeted medicine to show benefits in prostate cancer [Institute of Cancer Research]











5.12 IMMUNOTHÉRAPIES



VHIO investigators establish ‘user-friendly’ criteria to capture hyperprogression in patients treated with immune checkpoint inhibitors [VHIO]











5.12.1 IMMUNOTHÉRAPIES - PARTENARIATS



Seattle Genetics and Astellas Announce Clinical Trial Collaboration with Merck to Evaluate Enfortumab Vedotin in Combination with KEYTRUDA® (pembrolizumab) in Patients with Metastatic Urothelial Cancer [Astellas]











5.12.11 IMMUNOTHÉRAPIES - PRÉ-CLINIQUE



Researchers find protein promotes cancer, suppresses anti-tumor immunity [MD Anderson Cancer Center]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Novartis' new cell therapy facility could ease manufacturing squeeze for CAR-T med Kymriah [Fierce Pharma]










5.12.5 IMMUNOTHÉRAPIES - PHARMA



AstraZeneca wins speedy FDA review for Imfinzi to challenge Roche in small cell lung cancer [Fierce Pharma]











FDA Grants Priority Review to Merck’s Supplemental Biologics License Application (sBLA) for KEYTRUDA® (pembrolizumab) in Certain Patients with High-Risk, Non-Muscle Invasive Bladder Cancer (NMIBC) [Merck]











AstraZeneca gains a speedy Imfinzi review in race to beat Roche on frontline SCLC [EndPoints]











5.12.8 IMMUNOTHÉRAPIES - ECONOMIE



China gives Merck, BMS cold shoulder on reimbursement list as PD-1 battle enters new phase [Fierce Pharma]











Shaking up China's PD-(L)1 reimbursement landscape, Innovent, Eli Lilly earn coveted spot on national coverage [EndPoints]











5.16 TRAITEMENTS - CHIRURGIE



Stanford surgeons innovate new biological breast implants [Stanford]











5.2 PHARMA



Incyte Announces Acceptance and Priority Review of NDA for Pemigatinib as a Treatment for Patients with Cholangiocarcinoma [Incyte]











5.2.3 PHARMA - ÉCONOMIE



Roche under fire again: Mylan launches Herceptin copycat in latest blow to blockbuster trio [Fierce Pharma]











5.3 TRAITEMENTS - FDA, EMA, NICE...



FDA Finalizes Guidance on Adaptive Trial Designs [RAPS]











Making the case for ‘regulatory innovation’ in cancer research [Institute of Cancer Research]










5.4 TRAITEMENTS - ECONOMIE



NICE authorises Lynparza for NHS use in all BRCA-mutated ovarian cancer cases [Pharmafile]











5.8.2 ASH - PHARMA



Amgen Announces Data Being Presented At ASH 2019 [Amgen]











Novartis breadth of data at 2019 ASH demonstrates commitment to reimagining medicine in hematology through innovative therapeutic platforms [Novartis]











Astellas Presents New Data on XOSPATA® (gilteritinib) in FLT3 Mutation-Positive Relapsed/Refractory Acute Myeloid Leukemia at the 2019 American Society of Hematology Annual Meeting [Astellas]











6.1 OBSERVATION



People with Mental Illness Receive Less Cancer Screening [ESMO]











6.7.3 DMP



Amazon lets doctors record your conversations and put them in your medical files [CNBC]