Onco Actu du 2 décembre 2019

	2.11 ETIOLOGIE - ALIMENTATION
High-fat diet proven to fuel prostate cancer progression by imitating a key cancer alteration [McGill “In this paper, we showed that by mimicking a MYC overexpression, saturated fat intake makes prostate cancer worse.”
	3. PRÉVENTION
The Cancer Miracle Isn’t a Cure. It's Prevention. [Harvard Public Health] There are many reasons why prevention research is unenticing. Most societies are reactive, not proactive. The final phases of research on treatment are simpler than research on prevention. Curing a patient with advanced disease is more dramatic than preventing disease in a healthy person. And perhaps most conspicuously, treatments earn far higher profits than do new diagnostics or prevention measures.
	3.1.1 PRÉVENTION - TABAC - E-CIGS
How safe are e-cigarettes? [Imperial College London] “I think it’s fair to say that if you use a product from a reputable source to vape, then it’s going to be a lot less harmful to you, than if you were to use conventional cigarettes. By ‘a lot less harmful’, I can’t put a definite number on it, but I would say between probably no less than 90-95 per cent less harmful.”
Don't Toss That E-Cig: Vaping Waste Is A Whole New Headache For Schools and Cities [NPR] The extent of the trash reveals "how much this has become a part of our students' lives," Lewis says. "And that's what's scary... It really has become an epidemic in our schools, and not just here at Boulder High, but every high school in the nation is really dealing with this."
Nicotine sickness: the latest vaping scare [The Guardian] One major problem is trying to convince addicted teenagers to actually commit to quitting nicotine in the first place. But unless this happens, science suggests that many of these vapers will ultimately end up using both e-cigarettes and cigarettes, with potentially grave health consequences.
	4.1 DÉP., DIAG. & PRONO. - PROSTATE
Understanding PSA testing: A Q&A [Stanford] Issue number one is getting false positives -- and that happens a lot. For men with a high PSA, in the 4 ng/mL to 10 ng/mL range, we find cancer in about 25% of cases when we do a biopsy. That means there are a whole lot of guys who got a biopsy of their prostate that didn't need to.
	4.9 DÉP., DIAG. & PRONO. - SEIN
Randomised Trial of Supplemental MRI Screening in Women with Extremely Dense Breast Tissue [ESMO] The data from incident screening rounds and longer follow-up are needed in combination with simulation studies to assess the effect on the rate of advanced cancers and, eventually, on mortality.
	5. TRAITEMENTS
Targeted stem-cell attack could make transplants safer [Nature] Blood stem-cell transplants show promise for treating genetic and immune disorders, as well as cancers, but are currently risky.
	5.10 TRAITEMENTS - ESSAIS
UK head of Europe for early clinical research [PharmaTimes] Reasons such as Brexit and competition from countries like USA, Germany and Japan, as well as emerging heavy weights like China, are all cited as reasons the UK can’t seem to hold its competitive edge globally.
Calculating the Costs of Clinical Trials [ASH] ASH Clinical News recently spoke with several clinical trial and ethics experts about the hidden costs of clinical trial participation, the prices of post-trial access to investigational drugs, and some of the steps being taken to ease this burden.
	6. LUTTE CONTRE LES CANCERS
Scientist who helped develop new drug for ovarian cancer donates all profits to charity [The Independent] “I don’t think any scientist is driven by monetary considerations. What we’re driven by, largely, is finding things out. And the fact that we’ve hit gold with this drug is largely down to luck."