jeudi 19 décembre 2019

Onco Actu du 19 décembre 2019


1. BIOLOGIE



New study in mice points to why melanoma spreads — and perhaps how to prevent metastasis [STAT]










CRI scientists discover metabolic feature that allows melanoma cells to spread [UT Southwestern Medical Center]











When cells cycle fast, cancer gets a jumpstart [Yale Cancer Center]











1.4 BIOLOGIE - TECHNOS, MODÈLES



Study finds widespread misinterpretation of gene expression data [Tel Aviv University]











2.6 ETIOLOGIE - ENVIRONNEMENT



Roundup suit lawyer accused of $200 million extortion plot [CBS]










3.1 PRÉVENTION - TABAC



WHO launches new report on global tobacco use trends [WHO]











Tobacco epidemic at turning point as male smoking rates stall: WHO [Reuters]











3.1.1 PRÉVENTION - TABAC - E-CIGS



Special Report: FDA targets e-cigs that hook teens but don't help smokers quit [Reuters]











3.2 PRÉVENTION - OBÉSITÉ



Weight loss linked to lower chance of getting breast cancer for women over 50 [NHS Choices]











4. DÉPISTAGE, DIAGNOSTIC ET PRONOSTIC



Gastric cancer susceptibility marker discovered [Institut Pasteur]











4.12 BIOPSIES LIQUIDES



Circulating Tumor DNA May Be Predictive of Disease Progression in Patients with Rectal Cancer [AACR]











4.2 DÉP., DIAG. & PRONO. - GÉNOME



'Polygenic' profile could better predict disease risk for those with cancer mutations [Science]










4.3 DÉP., DIAG. & PRONO. - INDUSTRIELS



ArcherDX Announces Close of $55 Million Series C Financing [ArcherDx]











ArcherDX Raises $55M to Help Physicians Pick Best Cancer Therapies [Xconomy]











FTC Challenges PacBio Acquisition, Says Illumina is a “Monopolist” [Xconomy]











FTC calls out Illumina as 'monopolist,' moves to block $1.2B acquisition of PacBio [EndPoints]











4.5 DÉP., DIAG. & PRONO. - COLORECTAL



Recent Screening Rose among People under 50 after Release of New Colorectal Cancer Guidelines [ACS]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Bristol-Myers Squibb Announces Submission of Biologics License Application for CAR T-Cell Therapy Lisocabtagene Maraleucel (liso-cel) to FDA [BMS]











5.12.6 IMMUNOTHÉRAPIES - AMM



Merck's Keytruda nabs FDA panel's favor to line up for new bladder cancer OK [Fierce Pharma]











5.12.7 IMMUNOTHÉRAPIES - VACCINS



First-in-human trial for new lung cancer immunotherapy [Cancer Research UK]











5.2 PHARMA



After SABCS stunner, Seattle Genetics nabs FDA breakthrough tag for tucatinib [Fierce Biotech]











U.S. FDA Accepts and Grants Priority Review to sNDA for BRAFTOVI® (encorafenib) in Combination with ERBITUX® (cetuximab) (BRAFTOVI Doublet) for the Treatment of BRAFV600E-Mutant Metastatic Colorectal Cancer After Prior Therapy [Pfizer]











5.2.1 PHARMA - PARTENARIATS



Aduro stung as Novartis drops work on STING drug [Fierce Biotech]











After taking a hard look at the data, Novartis punts Aduro’s STING drug — the latest in a long line of setbacks [EndPoints]











5.2.2 PHARMA - FUSIONS & ACQUISITIONS



After being repeatedly jilted, this biotech was swept off its feet in a race to ASH: Inside Merck's $2.7B ArQule buyout [EndPoints]











5.3 TRAITEMENTS - FDA, EMA, NICE...



No OS benefit? No problem. FDA panel backs use of Lynparza in pancreatic cancer [EndPoints]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



European Commission approves Roche’s Kadcyla for the adjuvant treatment of people with HER2-positive early breast cancer with residual invasive disease after neoadjuvant treatment [Roche]











Seattle Genetics, Astellas snag quick FDA approval for bladder cancer-fighter Padcev [Fierce Pharma]











Tox issues? Check. Questionable efficacy data? Check. OK to market? ODAC says check that box for Epizyme [EndPoints]











FDA Grants Accelerated Approval to Astellas’ and Seattle Genetics’ PADCEV™ (enfortumab vedotin-ejfv) for People with Locally Advanced or Metastatic Urothelial Cancer, the Most Common Type of Bladder Cancer [Seattle Genetics]










FDA approves new type of therapy to treat advanced urothelial cancer [FDA]











Backed by Yale Cancer Center research, FDA approves new drug for advanced bladder cancer [Yale Cancer Center]











5.4 TRAITEMENTS - ECONOMIE



Low-cost breast cancer drug 'could save lives in low-income countries' [The Guardian]










WHO prequalifies first biosimilar medicine to increase worldwide access to life-saving breast cancer treatment [WHO]











5.9 AACR



2019 in Review: Progress Across Many Areas of Cancer Research [Cancer Research Catalyst]











6.1 OBSERVATION



Breast cancer survivors face other health risks after treatment [Reuters]











6.10.1 POLITIQUES (USA)



Trump Administration takes historic steps to lower U.S. prescription drug prices [FDA]











In a first step, Trump administration unveils two proposals to permit drug importation [STAT]











Top Republican blasts McConnell for derailing bipartisan drug pricing bill [STAT]











Trump Administration Takes First Step to Allow Drug Imports From Canada [NY Times]











Trump proposes rule for importing drugs from Canada; industry says it won't cut costs [Reuters]











6.6 PUBLICATIONS



Universal Principled Review: A Community-Driven Method to Improve Peer Review [Cell]










Politics and Open Access [The Scholarly Kitchen]











Science groups, senator warn Trump administration not to change publishing rules [Science]











6.7.3 DMP



Can AI Fix Medical Records? [Nature]










6.9 CONTROVERSES



Embattled cancer researcher loses legal bid to be reinstated as department chair at OSU [Retraction Watch]