mercredi 18 décembre 2019

Onco Actu du 18 décembre 2019


1. BIOLOGIE



New model explains how our immune system sometimes helps cancer spread [University of Alberta]











1.4 BIOLOGIE - TECHNOS, MODÈLES



Moffitt Researchers Develop More Efficient Approach to Create Mouse Models [Moffitt Cancer Center]











3.1.1 PRÉVENTION - TABAC - E-CIGS



One in five high school seniors vaped marijuana in the last year, fueling concern among health officials [STAT]











E-Cigarette Laws that Work for Everyone [Bill of Health]










Flavored E-Cigarette Bans are a Sure Way to Increase Youth Cigarette Consumption and Black Market THC Vaping [The Rest of The Story]











Teen Marijuana Vaping Soars, Displacing Other Habits [NY Times]











More than 20% of U.S. of high school seniors vaped THC in 2019: study [Reuters]











3.2 PRÉVENTION - OBÉSITÉ



Study Finds Losing Weight After 50 May Lower Breast Cancer Risk [ACS]










Sustained weight loss in middle-age may lower breast cancer risk [Reuters]











4.15 DÉP., DIAG. & PRONO. - IMAGERIE



AI, Accelerated Computing Drive Shift to Personalized Healthcare [Nvidia]











4.2 DÉP., DIAG. & PRONO. - GÉNOME



Rolling out genomic screening [BMJ]










4.3 DÉP., DIAG. & PRONO. - INDUSTRIELS



The FTC moves to block DNA sequencer Illumina’s acquisition of PacBio, calling company a ‘monopolist’ [STAT]











4.9 DÉP., DIAG. & PRONO. - SEIN



AI Improves Breast Cancer Risk Prediction [RSNA]











5.10 TRAITEMENTS - ESSAIS



World first treatment with ‘acoustic cluster therapy’ to improve chemotherapy delivery [Institute of Cancer Research]











5.12.4 IMMUNOTHÉRAPIES - ESSAIS



GSK's anti-BCMA med shrinks tumors in 31% of advanced multiple myeloma patients [Fierce Biotech]











GSK advances blood cancer drug to FDA, but rivals threaten [Biopharma Dive]










BCMA-Targeted Immunotherapy Can Lead to Durable Responses in Multiple Myeloma [Penn Medicine]











5.12.5.1 IMMUNOTHÉRAPIES - BIOTECH



Invectys publishes positive clinical results for its INVAC-1 Phase I Study in Clinical Cancer Research [Invectys]











ImmunoGen Announces Accelerated Approval Pathway for Mirvetuximab Soravtansine in Ovarian Cancer [ImmunoGen]











5.12.6 IMMUNOTHÉRAPIES - AMM



FDA Oncologic Drugs Advisory Committee (ODAC) Recommends KEYTRUDA® (pembrolizumab) for the Treatment of Certain Patients with High-Risk, Non-Muscle Invasive Bladder Cancer (NMIBC) [Merck]











5.2 PHARMA



FDA raises doubts about benefits of Epizyme's cancer drug ahead of AdComm [Fierce Biotech]











FDA’s in-house review offers bleak assessment of Epizyme’s tazemetostat — but win or lose this cancer drug may still have a future [EndPoints]











Eli Lilly spotlights early oncology in first pipeline review since R&D shift [EndPoints]











5.2.3 PHARMA - ÉCONOMIE



All hail drug reps: Most cancer docs rely on pharma salespeople for info, survey finds [Fierce Pharma]











5.2.6 PHARMA - BIOTECH



PharmaMar files for FDA approval of small cell lung cancer drug [Fierce Biotech]











No pain, no gain: Company building French VC scores €250M for life sciences fund [EndPoints]











5.3 TRAITEMENTS - FDA, EMA, NICE...



AZ, Merck's Lynparza narrowly snags FDA panel backing in pancreatic cancer [Fierce Pharma]










Lynparza recommended by FDA advisory committee for 1st-line maintenance treatment of germline BRCA-mutated metastatic pancreatic cancer [AstraZeneca]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



In crowded prostate cancer market, Pfizer's Xtandi notches third approval for use in earlier stage of disease [EndPoints]











5.6.7 ESMO - IMMUNOTHÉRAPIES



ESMO I-O: Roche silences Tecentriq doubters with latest lung cancer analysis [Fierce Pharma]











5.9 AACR



The AACR-MPM Oncology Charitable Foundation Announces First Grants to Support Transformative Cancer Research [AACR]











6.1 OBSERVATION



Patients with Acute Leukemia Who Are Treated with Common Therapy Have Increased Risk for Heart Failure [Penn Medicine]











6.7.1 IA/BIOINFORMATIQUE



Artificial Intelligence in Health Care - A Report From the National Academy of Medicine [JAMA]










6.7.3 DMP



Evaluating Improvements and Shortcomings in Clinician Satisfaction With Electronic Health Record Usability [JAMA Network Open]