lundi 4 novembre 2019

Onco Actu du 4 novembre 2019


1. BIOLOGIE



Kidney Cancer Study Uncovers New Subtypes and Clues to Better Diagnosis and Treatment [Johns Hopkins]











1.1 BIOLOGIE - GÉNOME



AACR Project GENIE Begins Five-year Collaborative Research Project with $36 Million in New Funding [AACR]











1.4 BIOLOGIE - TECHNOS, MODÈLES



Liquid-in-liquid printing method could put 3D-printed organs in reach [Science]











2. ETIOLOGIE



Some gut bacteria may increase bowel cancer risk, research suggests [The Guardian]











Researchers identify certain gut bacteria that may be involved in causing bowel cancer [NCRI]











2.13 ETIOLOGIE - NDMA



Statement on new testing results, including low levels of impurities in ranitidine drugs [FDA]











FDA downplays risks from already recalled heartburn drug Zantac [Reuters]











3.1.1 PRÉVENTION - TABAC - E-CIGS



Update: Characteristics of Patients in a National Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injuries — United States, October 2019 [CDC]











China Effectively Bans Online Sales of E-Cigarettes [NY Times]










Factbox: U.S. vaping-related deaths climb to 39, Illinois reports third death [Reuters]










3.3 PRÉVENTION - VACCINS



Merck again borrows Gardasil supplies from CDC [Biopharma Dive]











4.12 BIOPSIES LIQUIDES



Breast cancer may be detected by blood test five years before clinical signs show [The Guardian]











Simple blood test for early detection of breast cancer [NCRI]











4.9 DÉP., DIAG. & PRONO. - SEIN



Breast Cancer Recurrence Risk Predicted by Immune-Related Germline Variants [Genome Web]











5. TRAITEMENTS



HER2 Amplification Confers Drug Sensitivity Across Tumor Types in New Study [Genome Web]











Chemotherapy sometimes sets the stage for drug-resistant leukemia at relapse [St. Jude Children's Research Hospital]










5.10 TRAITEMENTS - ESSAIS



Seven Decades of Chemotherapy Clinical Trials: A Pan-Cancer Social Network Analysis [medRxiv]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Science author digs into the story about a revolutionary cancer treatment used in immunotherapy [Washington Post]











5.12.4 IMMUNOTHÉRAPIES - ESSAIS



Yale Cancer Center study shows checkpoint inhibitor prolongs survival in patients with certain head and neck cancers [Yale]










Durvalumab Plus Chemotherapy Improves Survival in Small Cell Lung Cancer [NCI]











5.12.5 IMMUNOTHÉRAPIES - PHARMA



Bristol-Myers warns I-O blockbuster Opdivo will be 'under pressure' in 2020 [Fierce Pharma]











5.17 TRAITEMENTS - RADIOTHÉRAPIE



ICR and The Royal Marsden form part of new radiotherapy research network after receiving major new funding [Institute of Cancer Research]











Personalised and powerful: UK to lead next-generation radiotherapy research [Cancer Research UK]










5.2 PHARMA



Is AbbVie's Imbruvica concerned about AZ's rising Calquence? We've got this covered, execs say [Fierce Pharma]











Sanofi's oncology R&D group marks a pair of setbacks on isatuximab/Libtayo combo as cancer studies fizzle out [EndPoints]











5.2.1 PHARMA - PARTENARIATS



Amgen's China ambitions become clear with BeiGene deal [Biopharma Dive]











Amgen acquires stake in BeiGene to expand cancer drug business to China [STAT]










Amgen takes a $2.7B stake in BeiGene, gaining a prominent ally in China to help seize a leading role in cancer drug commercialization and development [EndPoints]











Amgen takes 20.5% stake in BeiGene to sell cancer drugs in China [Reuters]











5.3 TRAITEMENTS - FDA, EMA, NICE...



Trump nominates MD Anderson’s Stephen Hahn to lead FDA [STAT]











MD Anderson's Hahn picked as next FDA commissioner [Fierce Biotech]











Right on deadline, Trump taps Stephen Hahn as new FDA commish. Now what? [EndPoints]











Sharpless to return to NCI as Hahn gets nominated as FDA commissioner, with Giroir to serve as acting [The Cancer Letter]











Trump to Nominate Stephen Hahn, Cancer Researcher, to Head F.D.A. [NY Times]










Trump nominates MD Anderson oncologist as U.S. FDA Commissioner [Reuters]











5.4 TRAITEMENTS - ECONOMIE



Drug shortages are worsening, and there are no simple solutions [Science-Based Medicine]











5.9 AACR



Targets Conference Showcases Exciting Data from Clinical Trials of Innovative Cancer Therapeutics [Cancer Research Catalyst]











6.1 OBSERVATION



Liver cancer deaths climb by around 50% in the last decade [Cancer Research UK]










Unhealthy lifestyles fuel a 50 per cent rise in UK deaths from liver cancer The Telegraph]











Sharp 80% rise in liver cancer deaths in UK [The Guardian]











6.6 PUBLICATIONS



Publish or perish: The cost of reformatting academic papers [Stanford]











6.7.1 IA/BIOINFORMATIQUE



AI will revolutionize drug discovery — but only if experts are involved [STAT]











6.7.3 DMP



The EMR has changed the doctor-patient duet into a ménage-à-trois [STAT]











Our Hospital’s New Software Frets About My ‘Deficiencies’ [NY Times]