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1. BIOLOGIE
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1.1 BIOLOGIE - GÉNOME
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2. ETIOLOGIE
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In the Pancreas, Common Fungi May Drive Cancer [NY Times]
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“We have to move from thinking about tumor cells alone to thinking of the whole neighborhood that the tumor lives in,” said Dr. Brian Wolpin. The interaction between microbes and their hosts is extremely complex, Dr. Miller said, and further experiments will be needed before the new findings can be applied in treating cancer patients.
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2.11 ETIOLOGIE - ALIMENTATION
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Meat’s Bad for You! No, It’s Not! How Experts See Different Things in the Data [NY Times]
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Because these questions don’t have black and white answers, researchers can look at the same sets of data and come to very different conclusions. Should recommendations be more concerned with populations or individuals? How much risk should there be to matter? Should personal preferences be considered? What should we say in the face of less than optimal evidence? Nothing? Play it safe?
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2.13 ETIOLOGIE - NMDA
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3.1.1 PRÉVENTION - TABAC - E-CIGS
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4.12 BIOPSIES LIQUIDES
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4.15 DÉP., DIAG. & PRONO. - IMAGERIE
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4.2 DÉP., DIAG. & PRONO. - GÉNOME
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Breast cancer: Call for genetic screening for all [BBC News]
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Currently, only those with risk factors such as a close family history of breast cancer are offered the check. Researchers say screening everyone would enable women to make informed treatment choices and allow family members to take preventative action.
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5.1 TRAITEMENTS - PRÉ-CLINIQUE
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Boxing move knocks cancer cells out [Netherlands Cancer Institute]
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In laboratory mice they combined a CDC7-inhibitor with an mTOR-inhibitor, both of which are already used in research and which have been individually tested on cancer patients. The result: twice as many mice survived in comparison with those receiving current standard treatment.
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5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES
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5.12.7 IMMUNOTHÉRAPIES - VACCINS
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Discovery may expand cancer vaccine capabilities [Arizona State University]
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They have found a common, new source of tumor mutations that could offer three levels of therapy with a cancer vaccine: 1) a broadly protective, or pan-cancer vaccine 2) cancer-type specific vaccines (e.g. breast vs. pancreatic) and 3) personalized cancer vaccines based on mutations unique to an individual.
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5.12.8 IMMUNOTHÉRAPIES - ECONOMIE
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5.2 PHARMA
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5.2.3 PHARMA - ÉCONOMIE
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After failed cancer test, Tocagen slashes staff [Fierce Biotech]
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This is a tough-to-treat cancer and has seen a growing pile of drugs miss their survival goals. But this failure cut deep for the biotech, and, to add to the woe, all secondary endpoints “showed no meaningful difference between the arms of the trial,” according to the brief update.
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5.3 TRAITEMENTS - FDA, EMA, NICE...
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6.1 OBSERVATION
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6.10.1 POLITIQUES (USA)
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6.6 PUBLICATIONS
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A kinder research culture is possible [Nature]
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Farrar concedes that a focus on excellence also contributes to “destructive hyper-competition, toxic power dynamics and poor leadership behaviour” — the latter echoing the findings from Nature’s comprehensive survey on research-group culture last year.
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6.7.1 IA/BIOINFORMATIQUE
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6.7.3 DMP
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