jeudi 24 octobre 2019

Onco Actu du 24 octobre 2019


1. BIOLOGIE



UChicago scientists unveil the secret of cancer-associated Warburg effect [University of Chicago]











1.1 BIOLOGIE - GÉNOME



Mutational Signatures Uncovered in Non-Cancerous Colon, Liver Tissue [Genome Web]











Genetic analysis explores links between liver disease and cancer [Cancer Research UK]










Uncovering the pathway to colon cancer [Sanger Institute]











1.1.1 BIOLOGIE - GÉNOME - MÉTASTASES



Nature publication: High resolution DNA-image of metastatic tumor provides new treatment insights [Hartwig Medical Foundation]










Metastatic Tumor Profiles Lead to Potential Treatment Targets [Genome Web]











2.13 ETIOLOGIE - NDMA



Pfizer, GSK, others face negligence suits over Zantac carcinogen testing [Fierce Pharma]











U.S. FDA says carcinogen not found in alternatives of Zantac and its generics [Reuters]











FDA releases additional NDMA testing method and alerts health care professionals and patients to multiple voluntary recalls of ranitidine [FDA]











3.1.1 PRÉVENTION - TABAC - E-CIGS



As Vaping Devices Have Evolved, So Have Potential Hazards, Researchers Say [NPR]











E-cigarette smoke associated with lung cancer, inflammation, as federal agencies respond to vaping deaths [The Cancer Letter]











4.12 BIOPSIES LIQUIDES



Guardant Health Initiates ECLIPSE Pivotal Study for its LUNAR-2 Blood Test for Colorectal Cancer Screening [Guardant Health]











4.3 DÉP., DIAG. & PRONO. - INDUSTRIELS



FDA Approves Myriad’s myChoice® CDx Test to Help Identify Women Eligible for Treatment with Zejula® in Late-line Ovarian Cancer [Myriad]











4.9 DÉP., DIAG. & PRONO. - SEIN



Sentinel lymph node biopsy has no benefits for stage zero breast cancer [Yale]











5.10 TRAITEMENTS - ESSAIS



Real-world data, evidence should be leveraged in clinical research to better include and ultimately treat larger patient populations [The Cancer Letter]











5.12.11 IMMUNOTHÉRAPIES - PRÉ-CLINIQUE



Clues to improve cancer immunotherapy revealed [WUSTL]











Scientists Discover Reasons Why Targeted Immuno-Oncology Drugs Sometimes Fail [Ohio State University]











5.2 PHARMA



After phase 3 bust, Lilly cans pancreatic cancer program for Armo buyout drug [Fierce Biotech]











5.2.6 PHARMA - BIOTECH



Rapt Therapeutics revives IPO, files to raise $75M [Fierce Biotech]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



GSK gets FDA nod for wider use of ovarian cancer drug Zejula [Reuters]











FDA approves niraparib for HRD-positive advanced ovarian cancer [FDA]










6.1 OBSERVATION



Number of Deaths, Incident Cases, and Disability-Adjusted Life-Years Caused by Pancreatic Cancer Has More Than Doubled From 1990 To 2017 [ESMO]










6.11 PATIENTS



A livestock-poison-turned-drug might save her from endless cancer surgeries. But if she helps test it, could she afford to keep taking it? [STAT]










6.2 IMPLANTS MAMMAIRES



Statement on the agency’s continued efforts to protect women’s health and enhance safety information available to patients considering breast implants [FDA]











FDA wants stronger warning on breast implants about risks [STAT]











Women Should Be Warned of Breast Implant Hazards, F.D.A. Says [NY Times]










6.6 PUBLICATIONS



A new look for Nature [Nature]











6.7 DMP, BIG DATA & APPLIS



Measuring Performance of OpenNotes Initiatives to Target Improvement Efforts [NEJM Catalyst]











6.7.1 IA/BIOINFORMATIQUE



Advancing AI in health care: It’s all about trust [STAT]