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1.4 BIOLOGIE - TECHNOS, MODÈLES
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3.1.1 PRÉVENTION - TABAC - E-CIGS
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Is It Time to Quit Vaping? [NY Times]
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Health officials have recommended that people refrain from using e-cigarettes as they investigate a severe lung illness that has killed eight people. Here are some things to consider.
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4.3 DÉP., DIAG. & PRONO. - INDUSTRIELS
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5. TRAITEMENTS
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Children being denied new cancer drugs [BBC News]
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It looked at samples from 223 children and analysed the DNA inside their tumours. The doctors were looking for mutations in 91 genes that can turn a cell cancerous and could potentially be treated with a targeted therapy. While the researchers found 51% of cases could have been treated with a precision drug, only 7% actually were.
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5.10 TRAITEMENTS - ESSAIS
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Cancer drug trials often at risk of bias, study finds [Biopharma Dive]
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Out of the 54 supporting pivotal studies for 32 cancer drugs approved in that time period, 41 were randomized controlled trials (RCTs). Researchers determined 49% of those RCTs were at high risk of bias, including studies of some prominent therapies such as Bristol-Myers Squibb's Opdivo, AbbVie's Imbruvica and Pfizer's Ibrance.
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5.12.13 IMMUNOTHÉRAPIES - BIOMARQUEURS
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5.2 PHARMA
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5.2.3 PHARMA - ÉCONOMIE
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Eying “Extra” DNA As Cancer Driver, Boundless Bio Debuts With $46M [Xconomy]
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“We’re targeting the actual process by which the oncogene products arrive in the first place,” Hornby says. “We’re cutting out the cell’s ability to create oncodrivers and mechanisms of evasion and resistance, and looking at it through this new lens has revealed novel targets—targets that, to our knowledge, no one has ever tried to pharmaceutically pursue, or drug.”
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A New Approach To Cancer Treatment [Boundless Bio]
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Boundless Bio is paving the way for a new understanding of extrachromosomal DNA, or ecDNA, one of the key drivers of the most aggressive cancers—specifically, those characterized by high copy number amplification of oncogenes.
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5.6 ESMO
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6.10.1 POLITIQUES (USA)
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6.6 PUBLICATIONS
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6.7 DMP, BIG DATA & APPLIS
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6.7.1 IA/BIOINFORMATIQUE
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New AI laboratory for the NHS [BMJ]
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AI is powered by data. Although the NHS potentially has the best health data in the world, local systems rarely communicate with each other, and the process of accessing and organising data for research is slow and costly. Harmonisation is a priority, but strategic questions remain.
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