mardi 17 septembre 2019

Onco Actu du 17 septembre 2019


1. BIOLOGIE



Biological mechanism explained: How lymphoma cells form brain metastases [DKFZ]











1.1 BIOLOGIE - GÉNOME



Mathematical model finds the cancer mutations that matter [Broad Institute]










1.5 PRIX LASKER



Lasker Award recipient had retracted some of his work — a sign of strength, not sloppiness [STAT]











2.5 ETIOLOGIE - GÈNES



Increased risk of prostate cancer in men with BRCA2 gene fault [Institute of Cancer Research]










3.1.1 PRÉVENTION - TABAC - E-CIGS



Health officials are hunting for the culprit behind vaping-related illnesses. Here are five questions about the outbreak [STAT]











Flavoring Ingredient Exceeds Safety Levels in E-Cigarettes and Smokeless Tobacco [Duke Health]











California governor acts to stem 'epidemic' of youth vaping [Reuters]











Mint, menthol e-cigarette liquids high in cancer-causing compound: study [Reuters]











4. DÉPISTAGE, DIAGNOSTIC ET PRONOSTIC



Only a third of women take up all offered cancer screenings, new research finds [King's College]










4.12 BIOPSIES LIQUIDES



Liquid Biopsy Uncovers Drug Resistance Mechanisms in GI Cancer Missed by Tissue Biopsy [Genome Web]











4.15 DÉP., DIAG. & PRONO. - IMAGERIE



Millions of Americans’ Medical Images and Data Are Available on the Internet. Anyone Can Take a Peek. [ProPublica]











4.3 DÉP., DIAG. & PRONO. - INDUSTRIELS



Myriad Announces Research Collaboration with University of Leeds [Myriad]











5. TRAITEMENTS



The Right Dose: Researching Cancer Treatment De-Escalation [Cancer Research Catalyst]











5.1 TRAITEMENTS - PRÉ-CLINIQUE



How an Altered Gatekeeping Protein Can Cause Cancer [Memorial Sloan Kettering]











Genetic Targeting Gives Cancer Therapy a Better Shot at Success [Duke]











5.10 TRAITEMENTS - ESSAIS



Amgen's Kyprolis, J&J's Darzalex team up on myeloma survival win [Fierce Pharma]











New DARZALEX® (daratumumab) Data from GRIFFIN Study Show High Response Rate and Depth of Response in Patients with Newly Diagnosed Multiple Myeloma Who are Transplant-Eligible [Janssen]











5.12.3 IMMUNOTHÉRAPIES-COMBINAISONS



After a run of CTLA-4 combo failures, scientists spotlight a way to make it work — in select patients [EndPoints]











5.12.8 IMMUNOTHÉRAPIES - ECONOMIE



CAR T cell immunotherapy now available through NHS Scotland for some adults with lymphoma [Cancer Research UK]











5.16 TRAITEMENTS - CHIRURGIE



New imaging technology could ‘revolutionize’ cancer surgery [University of Waterloo]











5.2 PHARMA



Seattle Genetics and Astellas Announce US FDA Grants Priority Review for Enfortumab Vedotin Biologics License Application in Locally Advanced or Metastatic Urothelial Cancer [Astellas]











Celgene's AML drug clears late-stage test [EndPoints]











Seattle Genetics/Astellas win priority US review for armed antibody aimed at bladder cancer [EndPoints]











5.2.1 PHARMA - PARTENARIATS



Breaking through limits in lung cancer: Introducing The Lung Ambition Alliance [Pharmafile]











5.3 TRAITEMENTS - FDA, EMA, NICE...



FDA warns about rare but severe lung inflammation with Ibrance, Kisqali, and Verzenio for breast cancer [FDA]










Three Breast Cancer Drugs: FDA Warns of Rare but Serious Lung Inflammation [RAPS]











5.4 TRAITEMENTS - ECONOMIE



Two lung cancer drugs approved and one rejected for NHS Scotland [Cancer Research UK]











5.6 ESMO



5 questions ESMO cancer drug data might answer [Biopharma Dive]










6.10.1 POLITIQUES (USA)



Federal “right-to-try” over a year later: Still a failure and still about the money (and weakening the FDA) [Science-Based Medicine]











6.3 ASSOCIATIONS/FONDATIONS



MMRF Research Programs Drives New Breakthroughs in Multiple Myeloma Research [MMRF]











6.6 PUBLICATIONS



New deals could help scientific societies survive open access [Science]











Ninth international congress on peer review and scientific publication: call for research [BMJ]











6.7.1 IA/BIOINFORMATIQUE



Artificial Intelligence Confronts a 'Reproducibility' Crisis [Wired]











6.7.3 DMP



Ease financial toxicity by putting electronic medical records to work [STAT]