vendredi 2 août 2019

Onco Actu du 2 août 2019


1. BIOLOGIE



Protective protein not only guards against DNA damage, but could help better target fast-growing cancer cells [University of Sussex]











UC researchers unlock cancer cells’ feeding mechanism [University of Cincinnati]











1.4 BIOLOGIE - TECHNOS, MODÈLES



Using a more diverse microbiome, scientists look to create a better lab mouse [STAT]











New Mouse Model Predicts Two Clinical Trial Failures in Humans [The Scientist]











Could lab mice born to wild parents improve the search for human cures? [Science]










“Wildling” mice could help translate results in animal models to results in humans [NIH]











2. ETIOLOGIE



How a 6,000-Year-Old Dog Cancer Spread Around the World [Wired]











Cancer without end? Discovery yields fresh insights [MedicalXpress]











3.3 PRÉVENTION - VACCINS



Merck's spending big to support Gardasil, and the HPV vaccine keeps pumping along [Fierce Pharma]










3.4.1 CHIMIOPRÉVENTION - ASPIRINE



Colorectal cancer: diagnosis and management (update) [NICE]











Prescribe daily aspirin to prevent colorectal cancers, doctors told [The Telegraph]











4.12 BIOPSIES LIQUIDES



Personalised ‘liquid biopsy’ could detect return of breast cancer nearly eleven months earlier than hospital scans [Institute of Cancer Research]










4.15 DÉP., DIAG. & PRONO. - IMAGERIE



New imaging method is more effective at detecting prostate cancer recurrence than standard scan [UCLA]










5.10 TRAITEMENTS - ESSAIS



Ibrutinib–Rituximab Improves Survival Compared With Current Treatment for Chronic Lymphocytic Leukemia [AJMC]











5.12.5 IMMUNOTHÉRAPIES - PHARMA



Nektar Therapeutics and Bristol-Myers Squibb Announce U.S. FDA Breakthrough Therapy Designation for Bempegaldesleukin (NKTR-214) in Combination with Opdivo® (nivolumab) for the Treatment of Patients with Untreated Advanced Melanoma [BMS]











5.12.8 IMMUNOTHÉRAPIES - ECONOMIE



Janssen returns rights for experimental cancer immunotherapy to Alligator Bioscience, sending shares spiraling by 40% [Pharmafile]











ImCheck Therapeutics Awarded €2 Million From Bpifrance To Advance Its First-In Class Immunotherapy Program Into The Clinic [ImCheck]











5.17 TRAITEMENTS - RADIOTHÉRAPIE



Inconsistent Reporting of Methodologies Makes Most Radiation Biology Studies Impossible to Replicate [University of Maryland]











5.2 PHARMA



Still trailing far behind a blockbuster rival, Novartis gathers another round of positive survival data for Kisqali [EndPoints]











5.3 TRAITEMENTS - FDA, EMA, NICE...



FDA-EMA workshop discusses quality challenges for PRIME, breakthrough therapies [EndPoints]











5.4 TRAITEMENTS - ECONOMIE



A watchdog group sets aside emotions to assess drugs’ value. Patients say their lives are more than a number [STAT]











6.1 OBSERVATION



Stress in Cervical Cancer Patients is Associated With Higher Risk of Cancer-specific Mortality [AACR]











Families seek answers for US rise in childhood cancers [The Guardian]











6.10.1 POLITIQUES (USA)



White House Floats Canadian Import Plan But Excludes Many Costly Drugs [Xconomy]











6.9 CONTROVERSES



The untold story of the ‘circle of trust’ behind the world’s first gene-edited babies [Science]