jeudi 1 août 2019

Onco Actu du 1er août 2019


1.1 BIOLOGIE - GÉNOME



Over 100,000 whole genome sequences now available for approved researchers [Genomics England]










3.3 PRÉVENTION - VACCINS



Just One HPV Dose May Be Enough To Prevent Several Cancers [Forbes]










4. DÉPISTAGE, DIAGNOSTIC ET PRONOSTIC



Roswell Park Team Develops New Method of Tracking Cellular Changes Associated with Cancer [Roswell Park]











4.7 DÉP., DIAG. & PRONO. - COL DE L'UTÉRUS



A new choice for young women with pre-cancerous cervical disease [Queen Mary University of London]











4.9 DÉP., DIAG. & PRONO. - SEIN



AI Improves Efficiency and Accuracy of Digital Breast Tomosynthesis [RSNA]











5.1 TRAITEMENTS - PRÉ-CLINIQUE



‘Promising’ antibody therapy extends survival in mice with pancreatic cancer [Pancreatic Cancer Research Fund]











5.10 TRAITEMENTS - ESSAIS



Novartis' Kisqali sharpens survival edge with second ph3 win [Fierce Pharma]











Novartis Kisqali significantly prolongs life in women with HR+/HER2- advanced breast cancer now in two distinct Phase III trials [Novartis]











Drug combo heralds major shift in chronic lymphocytic leukemia treatment [Stanford Medicine]











5.12 IMMUNOTHÉRAPIES



Immunogenicity Prediction in BRCA Deficient Breast Cancer [ESMO]











The good, the bad, and the ugly: hyperprogression in cancer patients following immune checkpoint therapy [Genome Medicine]










5.12.11 IMMUNOTHÉRAPIES - PRÉ-CLINIQUE



New ‘don’t eat me’ signal may provide basis for cancer therapies [Stanford Medicine]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Car-T sales have disappointed, but has the sellside’s outlook shifted enough? [Vantage]











Swiss to Take On Big Pharma With Cheaper Cancer Treatment [Bloomberg]











5.12.6 IMMUNOTHÉRAPIES - AMM



FDA Approves New Monotherapy Indication for Merck’s KEYTRUDA® (pembrolizumab) [Merck]











Merck's Keytruda makes the cut as a second-line monotherapy for certain esophageal cancer patients [EndPoints]











FDA approves pembrolizumab for advanced esophageal squamous cell cancer [FDA]










5.2 PHARMA



Amgen plans pivotal lung cancer trial for its pipeline star [Biopharma Dive]











Pedal to the metal, Amgen finally has a hot new drug star on its hands — and they have some news [EndPoints]











5.2.1 PHARMA - PARTENARIATS



Exelixis and Aurigene Enter Into Exclusive Collaboration, Option and License Agreement to Discover and Develop Novel Therapies for Cancer [Exelixis]











5.3 TRAITEMENTS - FDA, EMA, NICE...



Supporting medicine developers in generating quality data packages in early access approaches (PRIME and breakthrough therapies): workshop report published [EMA]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



Bayer, Orion win speedy approval for prostate cancer drug darolutamide [EndPoints]











6.1 OBSERVATION



Colorectal Cancer Rises Among Younger Adults [NY Times]










6.10 POLITIQUES



Opinion: ‘Building an NHS workforce for the future must be Boris Johnson’s top health priority’ [Cancer Research UK]











6.10.1 POLITIQUES (USA)



Everything (or almost everything) you need to know about importing drugs from Canada [STAT]











Would Trump's new drug-imports plan do much to prices—or to pharma? [Fierce Pharma]











‘Don’t be a Bernie Bro’: Inside conservatives’ brazen campaign to sabotage Trump’s signature drug pricing plan STAT











Trump Administration, In Shift, Announces Plan To Permit Drug Importation [Health Affairs]










Trump Administration Weighs Allowing Drug Imports for Cheaper Prescriptions [NY Times]











FDA chief backs 2 new pathways to spur drug importation — but analysts shrug it all off [EndPoints]











Trump firms up plan to import medicines; pharma companies resist [Reuters]











6.12 ETHIQUE



New ASCO Statement Lays Out Framework for Including Research Biopsies in Clinical Trials [ASCO]










Time to discuss consent in digital-data studies [Nature]











6.7 DMP, BIG DATA & APPLIS



NIH-funded project aims to build a ‘Google’ for biomedical data [STAT]










Accelerating Innovation in Science [National Library of Medicine]