jeudi 4 juillet 2019

Onco Actu du 4 juillet 2019


1.1 BIOLOGIE - GÉNOME



Research Clarifies How IDH Mutations Cause Cancer [Memorial Sloan Kettering Cancer Center]











Ovarian and breast cancer research finds new ways BRCA1 gene functions [University of Birmingham]











2.6 ETIOLOGIE - ENVIRONNEMENT



U.S. judge to slash $80 million Roundup jury verdict: court hearing [Reuters]











3.1.1 PRÉVENTION - TABAC - E-CIGS



Juul Doesn't Need To Advertise To Young People. Everyone Else Is Doing It For Them [NPR]











3.2 PRÉVENTION - OBÉSITÉ



Obesity rivals smoking as cause of cancer, UK charity warns [The Guardian]











3.8 PRÉVENTION - ALIMENTATION



Men who eat yogurt may have lower colon cancer risk [Reuters]











4.2 DÉP., DIAG. & PRONO. - GÉNOME



New name for breast-cancer syndrome could help to save lives [Nature]










5.1 TRAITEMENTS - PRÉ-CLINIQUE



Imprinted Spheres Fight Breast Cancer: Inhibition of HER2 on tumor cells by molecularly imprinted nanoparticles [Wiley]











Novel computer model supports cancer therapy [University of Luxembourg]











High doses of 60-plus year-old chemotherapy drug found to spur immune system attack on lymphoma [Dana-Farber Cancer Institute]











5.10 TRAITEMENTS - ESSAIS



Boston Biomedical's lead drug fizzles in difficult-to-treat pancreatic cancer [EndPoints]











Stephenson Cancer Center Physician Is Lead Author of New Study Showing Drug Prolongs Life for Patients With Ovarian Cancer [Stephenson Cancer Center]











Attempt to replicate clinical trials with real-world data generates real-world criticism, too [STAT]











5.12 IMMUNOTHÉRAPIES



Immunotherapy for Urothelial Cancer: Where Are the Randomized Trials? [JCO]










5.12.11 IMMUNOTHÉRAPIES - PRÉ-CLINIQUE



Drug That Hits CAR T Snooze Button Can Quiet a Cytokine Storm [Memorial Sloan Kettering Cancer Center]










Bacteria Engineered as Trojan Horse for Cancer Immunotherapy [Columbia University]











Immune-boosting compound makes immunotherapy effective against pancreatic cancer [Washington University]











New Weapons Against Cancer: Millions of Bacteria Programmed to Kill [NY Times]










5.12.8 IMMUNOTHÉRAPIES - ECONOMIE



Innovation Prizes To Support Cell And Gene Therapy [Health Affairs]










5.3 TRAITEMENTS - FDA, EMA, NICE...



Call for all sponsors to publish clinical trial results in EU database [EMA]










5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



Karyopharm bags an upset win at the FDA as regulators OK myeloma drug despite a host of objections [EndPoints]











Karyopharm Therapeutics prices blood cancer treatment after FDA approval [Reuters]











FDA grants accelerated approval to selinexor for multiple myeloma [FDA]










6.1 OBSERVATION



Hormone Therapy for Prostate Cancer Tied to Dementia [NY Times]











Risk of dementia rises with prostate cancer hormone-blocking therapy [Reuters]











6.4 MÉDICO-ÉCO



The Costs of Cancer in 2015: 8.7 Million Years of Life and $94 Billion in Lost Earnings [ACS]











Cancer deaths in the U.S. cost $94B in lost earnings in 2015 [UPI]











6.7.1 IA/BIOINFORMATIQUE



Oncologists are guardedly optimistic about AI. But will it drive real improvements in cancer care? [STAT]











6.8 COMMUNICATION



Facebook joins Google in deprioritizing medical misinformation: Are social media companies finally “getting it”? [Respectful Insolence]