mercredi 3 juillet 2019

Onco Actu du 3 juillet 2019


1. BIOLOGIE



Metabolic signal curbs cancer-cell migration [Nature]











2.11 ETIOLOGIE - ALIMENTATION



Do Antioxidants Cause Lung Cancer to Spread? [Moffitt Cancer Center]











3.1 PRÉVENTION - TABAC



Austria passes smoking ban, snuffing out fallen government's flagship policy [Reuters]











3.1.1 PRÉVENTION - TABAC - E-CIGS



What do we really know about vaping? [Mosaic]











3.2 PRÉVENTION - OBÉSITÉ



Obesity overtakes smoking as the leading cause of four major cancers [The Telegraph]











Obesity 'causes more cases of some cancers than smoking' [BBC News]











Obese people outnumber smokers two to one [Cancer Research UK]










3.3.2 PRÉVENTION - VACCINS (OBSERVATION)



Population-level Impact of HPV Vaccination [ESMO]











4. DÉPISTAGE, DIAGNOSTIC ET PRONOSTIC



Study Probes How to Tell Elderly Patients Not to Bother With Cancer Screening [Johns Hopkins]











4.10 DÉP., DIAG. & PRONO. - POUMON



Study Compares USPSTF, Other Lung Cancer Screening Guidance [AAFP]











National Lung Screening Trial Follow Up Reaffirms that Low Dose Computed Tomography Reduces Lung Cancer Mortality [IASLC]











4.12 BIOPSIES LIQUIDES



Low-Frequency TP53 Gene Mutations Found in Women With, Without Cancer [Genome Web]











5.1 TRAITEMENTS - PRÉ-CLINIQUE



Docs should consider a patient’s weight before prescribing new chemotherapy drugs [University of Illinois]










5.10 TRAITEMENTS - ESSAIS



Boston Biomedical, Inc. Announces Update on Phase 3 CanStem111P Study of Napabucasin in Patients with Metastatic Pancreatic Cancer Following Interim Analysis [Boston Biomedical]











Another effort on pancreatic cancer flops, as Boston Biomedical cans phase 3 combo test [Fierce Biotech]










5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Iovance Biotherapeutics Provides Cervical Cancer Program Updates Following End of Phase 2 Meeting with U.S. Food and Drug Administration (FDA) [Iovance]











Emboldened by ASCO data, FDA etches speedy approval path for Iovance's cervical cancer therapy [EndPoints]











5.12.5 IMMUNOTHÉRAPIES - PHARMA



Incyte flips China rights of MacroGenics' PD-1 to an ambitious Zai Lab keen on leapfrogging pioneers with combos [EndPoints]











5.2 PHARMA



Sandoz launches oncology generic gefitinib in 13 EU countries at loss of market exclusivity, expanding access to essential medicine [Novartis]











5.2.1 PHARMA - PARTENARIATS



CRUK invests in SV fund, pushing it closer to $250M target [Fierce Biotech]











Cancer Research UK forms collaboration with SV Health Investors to accelerate development of cancer medicines [Cancer Research UK]











SV joins CRUK on a $250M-plus fund with an eye on developing new cancer drugs [EndPoints]











5.3 TRAITEMENTS - FDA, EMA, NICE...



Exclusive: FDA enforcement actions plummet under Trump [Science]











5.4 TRAITEMENTS - ECONOMIE



Sanofi, Regeneron's Libtayo hits hot streak with EU green light, NICE backing [Fierce Pharma]











6. LUTTE CONTRE LES CANCERS



Not old, just older: considering age in cancer care [Lancet Oncology]










6.10.1 POLITIQUES (USA)



Warren blasts Gottlieb's jump to Pfizer, but ex-FDA chief says he's 'proud' [Fierce Pharma]











Elizabeth Warren Calls on Former F.D.A. Chief to Quit Pfizer Board [NY Times]











6.6 PUBLICATIONS



Why India is striking back against predatory journals [Nature]











6.7 DMP, BIG DATA & APPLIS



NHS must take urgent steps to defend against hackers, says White Paper [Imperial College London]










Hackers could invade NHS systems to 'fake' or hide cancer on scans [The Telegrah]











6.8 COMMUNICATION



Using Facts to Promote Cancer Prevention on Social Media Is More Effective Than Personal Stories [UC Davis]











Addressing Sensational Health Claims [Facebook]











Facebook to tackle content with misleading health claims [Reuters]