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1. BIOLOGIE
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2.7 ETIOLOGIE - OBÉSITÉ
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Measure waist size, not BMI to gauge risk of early death, new study shows [The Telegraph]
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A team at the University of Iowa examined data from nearly 157,000 postmenopausal women who were followed for up to 20 years. They found that those with a BMI reading of less than 25 but a waist circumference of 35 inches or greater were at a 31 per cent higher risk of dying during the study period than women of a normal weigh and a waist of less than 35 inches.
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3.8 PRÉVENTION - ALIMENTATION
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4.12 BIOPSIES LIQUIDES
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Freenome Snags $160M to Boost Blood Test for Early Cancer Detection [Xconomy]
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A newcomer to the field, Cambridge, MA-based startup Thrive Earlier Detection, made its debut in May with a $110 million Series A fundraising round to advance a test first developed at Johns Hopkins University. Freenome’s test, like that of Thrive, analyzes a blood sample not just for DNA shed by cancer cells but also for proteins that could be additional cancer biomarkers.
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4.9 DÉP., DIAG. & PRONO. - SEIN
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5.1 TRAITEMENTS - PRÉ-CLINIQUE
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Outcompeting cancer using a novel cell-competition mechanism [ecancer News]
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"We first identified this 'fitness fingerprints' mechanism in the model animal Drosophila melanogaster (the common fruit fly), in 2010, and now, in this study published in the journal Nature, we were able to prove that it also exists in humans and that blocking it halts the growth of human cancer cells."
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5.10 TRAITEMENTS - ESSAIS
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5.12 IMMUNOTHÉRAPIES
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5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES
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5.12.4 IMMUNOTHÉRAPIES - ESSAIS
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Bristol, With Another Lung Cancer Flop, Loses More Ground to Merck [Xconomy]
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The test was a critical part of Bristol’s massive three-part Phase 3 trial, Checkmate-227, which has the fates of three different Bristol drug regimens riding on it. The Checkmate-227 lung cancer trial has studied nivo alone; a combination of nivo and chemo; and a regimen of two Bristol immunotherapies—nivo and ipilimumab (Yervoy).
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5.12.5 IMMUNOTHÉRAPIES - PHARMA
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5.16 TRAITEMENTS - CHIRURGIE
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5.3 TRAITEMENTS - FDA, EMA, NICE...
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6.1 OBSERVATION
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Relaxed UK salt policy tied to more heart disease, cancers [Reuters]
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From 2011 to 2018, the smaller yearly reductions in sodium intake may have been responsible for approximately 9,000 additional cases of cardiovascular disease and 1,500 more cases of gastric cancer than would have occurred under the previous salt policy, the study team reports in the Journal of Epidemiology & Community Health.
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6.2 IMPLANTS MAMMAIRES
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Allergan recalls textured breast implants worldwide [Reuters]
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Demand for Allergan’s smooth implants may be impacted and litigation claims may rise due to the recall, Stifel analyst Annabel Samimy said, but added that a direct impact from the recall was negligible for the company, which is being bought by AbbVie Inc for $63 billion.
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