vendredi 28 juin 2019

Onco Actu du 28 juin 2019


1. BIOLOGIE



Newly Defined Cancer Driver is Fast, Furious and Loud [University of Michigan]











In fighting cancer, look to what other animals do [The Economist]











Nutritional cues regulate pancreatic tumor’s “cell drinking” [Sanford Burnham Prebys]











1.1 BIOLOGIE - GÉNOME



Many Recurrent Cancer Mutations May Be Passengers, Not Drivers, Study Finds [Genome Web]











Mutational "hotspots" in cancer genomes may not necessarily drive cancer growth [Mass. General Hospital]










1.4 BIOLOGIE - TECHNOS



A Completely New Way to Picture DNA in Cells [In The Pipeline]











3.3 PRÉVENTION - VACCINS



The time is now to take a shot at eliminating six cancers caused by HPV [STAT]











3.3.2 PRÉVENTION - VACCINS (OBSERVATION)



Success of HPV vaccine could lead to end of cervical cancer [NHS Choices]











HPV Vaccines Are Reducing Infections, Warts — and Probably Cancer [NY Times]










3.8 PRÉVENTION - ALIMENTATION



10 Ways to Lower the Cancer Risk of Grilling [NY Times]











4.1 DÉP., DIAG. & PRONO. - PROSTATE



Prolaris® Test Accurately Predicts Risk of Metastasis in Men Diagnosed with Localized Prostate Cancer [Myriad]











4.10 DÉP., DIAG. & PRONO. - POUMON



Risk Prediction Model May Help Determine if a Lung Nodule Will Progress to Cancer [AACR]











Lung cancer screening guidelines may miss more African Americans at risk [Reuters]











4.15 DÉP., DIAG. & PRONO. - IMAGERIE



One Simple Change Cut Unnecessary Imaging for Cancer Patients in Half [Penn Medicine]











4.2 DÉP., DIAG. & PRONO. - GÉNOME



Molecular Profiling in Routine Practice for Advanced Cancers [ESMO]










Researchers criticize study calling for expansion of genetic testing for breast cancer [MedicalXpress]











4.9 DÉP., DIAG. & PRONO. - SEIN



Biomarkers of DNA methylation can be a predictor of breast cancer risk [VUMC]











5. TRAITEMENTS



Two-in-one drug combining Herceptin with chemotherapy keeps women’s breast cancers at bay [Institute of Cancer Research]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



OncoSec Receives Exclusive Licensing Rights from Dana-Farber Cancer Institute to CAR T-Cell Therapies for the Treatment of Solid Tumor Cancers [OncoSec]











5.12.5 IMMUNOTHÉRAPIES - PHARMA



AstraZeneca’s Imfinzi tees up small cell lung cancer fight with Roche [Fierce Pharma]










AstraZeneca gets immuno-oncology win in a disease that Merck doesn't rule [Biopharma Dive]











Imfinzi improves overall survival at interim analysis in the Phase III CASPIAN trial in 1st-line extensive-stage small cell lung cancer [AstraZeneca]











AstraZeneca challenges Roche on frontline SCLC after seizing an interim win — and Merck may not be far behind [EndPoints]











5.2 PHARMA



Innate Pharma announces publication of IPH4102 Phase I clinical trial results for CTCL in the Lancet Oncology [Innate Pharma]











5.2.3 PHARMA - ÉCONOMIE



ImmunoGen cuts deep to eke out cash for mirvetuximab trial [Fierce Biotech]











ImmunoGen to lay off 220 workers, as it pushes ahead with troubled drug [Biopharma Dive]











ImmunoGen Announces Completion of Operational Review [ImmunoGen]











Turned back at the FDA, ImmunoGen is axing 220 staffers, selling programs and hunkering down for a new PhIII gamble [EndPoints]











5.3 TRAITEMENTS - FDA, EMA, NICE...



Former FDA head Gottlieb to join Pfizer board [Biopharma Dive]











Scott Gottlieb walks through the revolving door to the Pfizer board [STAT]











Scott Gottlieb tempts the FDA's fiercest critics with his leap onto Pfizer's board of directors [EndPoints]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



Janssen Announces U.S. FDA Approval of DARZALEX® (daratumumab) in Combination with Lenalidomide and Dexamethasone for Newly Diagnosed Patients with Multiple Myeloma Who Are Transplant Ineligible [Janssen]











5.4 TRAITEMENTS - ECONOMIE



Negotiating drug prices without restricting patient access: lessons from Germany [STAT]










6. LUTTE CONTRE LES CANCERS



Guiding Cancer Control A Path to Transformation (2019) [National Academies Press]










6.9 CONTROVERSES



Potential class action lawsuit accuses the University of Chicago of sharing identifiable patient data with Google [STAT]