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1. BIOLOGIE
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Cancer genes help deer antlers grow [Science]
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“Deer antlers are using essentially a controlled form of bone cancer growth,” says Edward Davis, an evolutionary paleobiologist at the University of Oregon in Eugene who was not involved with the work. The involvement of the tumor-promoting genes isn’t surprising, he says; what’s surprising is the involvement of the cancer-controlling genes.
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God doesn’t play dice. Does cancer? [University of Colorado]
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“What was really striking to us is that if you normalize all the cancer incidences, they all fall on top of each other – for different cancers that require such a different number of drivers and that arise from stem cell pools that range thousands of times in size, incidence is the same across age,” says CU Cancer Center Deputy Director, James DeGregori, PhD. “What this means is that, mathematically, one cannot account for carcinogenesis simply with mutation accumulation over age.”
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1.4 BIOLOGIE - TECHNOS
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A new ‘DNA microscope’ peers deep inside living cells [STAT]
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Almost unheard of in this era of collaborations that are often larger than a soccer team, Weinstein, a postdoctoral fellow, worked virtually alone at the lab bench, advised by the Broad’s Aviv Regev and Feng Zhang. The Broad has applied for a patent on the invention.
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DNA Microscope Sees ‘Through the Eyes of the Cell’ [NY Times]
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“DNA microscopy captures both genetic and spatial information simultaneously,” said Joshua Weinstein, a postdoctoral researcher at the Broad Institute of M.I.T. and Harvard and the lead author of the paper. “That’s what’s really beautiful about it.”
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2. ETIOLOGIE
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2.5 ETIOLOGIE - GÈNES
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Which Genetic Syndromes Can Increase a Child’s Risk of Cancer? [Dana-Farber Cancer Institute]
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Inherited cancers account for at least 5 to 10 percent of all pediatric cancers. The same advances in technology that have enabled scientists to decode the human genome now allow doctors to determine when a child has been born with an error (mutation) in a specific gene that puts them at increased risk of childhood cancer. Researchers have identified over 100 genes that can cause specific cancer predisposition syndromes if a mutation is present.
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4. DÉPISTAGE, DIAGNOSTIC ET PRONOSTIC
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Improving Cancer Diagnosis and Care [National Academies Press]
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The first workshop focused on patient access to expertise and technologies in oncologic imaging and pathology and was held in February 2018. The second workshop, conducted in collaboration with the Board on Mathematical Sciences and Analytics, was held in October 2018 to examine the use of multidimensional data derived from patients with cancer, and the computational methods that analyze these data to inform cancer treatment decisions.
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4.11 DÉP., DIAG. & PRONO. - OVAIRE
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4.12 BIOPSIES LIQUIDES
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4.3 DÉP., DIAG. & PRONO. - INDUSTRIELS
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5. TRAITEMENTS
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5.10 TRAITEMENTS - ESSAIS
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5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES
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5.12.5 IMMUNOTHÉRAPIES - PHARMA
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5.2 PHARMA
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5.4 TRAITEMENTS - ECONOMIE
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6. LUTTE CONTRE LES CANCERS
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Federally funded research drives nearly one-third of U.S. patents, report finds [STAT]
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The authors of the new study, published Thursday in Science, examined millions of U.S. patents granted between 1926 and 2017, as well as related papers and reports, to glean which ones were supported by federal funding: patents owned by the government, those acknowledging federal support, and those that directly cite patents or papers acknowledging such support.
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6.1 OBSERVATION
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Nearly 5.4 Million Cancer Survivors Suffer Chronic Pain [ACS]
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Overall, 1,648 of the 4,526 cancer survivors identified in the survey (34.6%) reported having chronic pain; 768 of the survivors (16.1%) reported having high impact chronic pain. Applied to the nation as a whole, those rates equal approximately 5.39 million and 2.51 million cancer survivors, respectively, in the U.S.
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6.10.1 POLITIQUES (USA)
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6.6 PUBLICATIONS
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Hilda Bastian: Should we trust meta-analyses with meta conflicts of interest? [BMJ]
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Systematic reviewers and meta-analysts are widely seen as arbiters on the state of knowledge. This influence makes conflict of interest an acute issue for them in general. Yet as well as the usual author conflicts, they can have a type of potential conflict that’s totally meta and unique to them: being an author of the very studies they are choosing and weighing up.
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