mardi 18 juin 2019

Onco Actu du 18 juin 2019


1. BIOLOGIE



Most metastatic colorectal cancers have spread before diagnosis [Stanford Medicine]










Metastases May Form Early in Development of Colorectal Cancer [Genome Web]











Some Colorectal Cancers Are "Born To Be Bad," Have Already Spread Long Before Diagnosis [Forbes]











1.1 BIOLOGIE - GÉNOME



Out of Many Ovarian Precancerous Lesions, One Becomes Cancer [Johns Hopkins]











2.7 ETIOLOGIE - OBÉSITÉ



Excess Body Fat Tied to Fatal Prostate Cancers [NY Times]











4.15 DÉP., DIAG. & PRONO. - IMAGERIE



Artificial intelligence could revolutionize medical care. But don’t trust it to read your x-ray just yet [Science]










4.2 DÉP., DIAG. & PRONO. - GÉNOME



University of Glasgow Team to Integrate Genomics Into New Cancer Clinical Trials Network [Genome Web]











5. TRAITEMENTS



WVU researcher studies new treatment for pancreatic cancer [West Virginia University]











5.1 TRAITEMENTS - PRÉ-CLINIQUE



These Protein Picker-Uppers Keep Your Cells Clean and Healthy [Wired]











5.12.1 IMMUNOTHÉRAPIES - PARTENARIATS



Celgene hands PD-1 tislelizumab med back to BeiGene, forfeiting $150M [Fierce Biotech]











Celgene dips out of deals ahead of mega-merger [Biopharma Dive]











Celgene Hands Cancer Drug Back to BeiGene, Plus $150 Million [Bloomberg]











5.12.11 IMMUNOTHÉRAPIES - PRÉ-CLINIQUE



Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer [Memorial Sloan Kettering Cancer Center]










5.12.4 IMMUNOTHÉRAPIES - ESSAIS



Immunotherapy Study for Prostate Cancer Active Surveillance Completes Enrollment [Candel]











5.2 PHARMA



AstraZeneca's Calquence sets Imbruvica in its sights with big CLL survival numbers [Fierce Pharma]











Boehringer Ingelheim and OSE Immunotherapeutics Announce Dosing Of the First Patient in a Phase 1 Trial of SIRPα Antagonist Monoclonal Antibody, BI 765063, in Patients with Advanced Solid Tumors [Boehringer Ingelheim]











5.2.1 PHARMA - PARTENARIATS



French drugmaker Sanofi, Google to use data tech for innovations [Reuters]











5.2.2 PHARMA - FUSIONS & ACQUISITIONS



Colorectal Cancer Data Spurs Pfizer to Pay $11.4B for Array Bio [Xconomy]











Pfizer goes big on targeted cancer therapies with $11.4B Array buy [Biopharma Dive]











Pfizer CEO Albert Bourla is back in the M&A game, but why is he paying $11.4B for Array? [EndPoints]











Pfizer to Acquire Array BioPharma [Pfizer]











Pfizer spends $11.4 billion to buy Array BioPharma for its cancer drug chemistry [STAT]










5.2.3 PHARMA - ÉCONOMIE



Innovation, at Universities and in Industry [In The Pipeline]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



Lynparza approved in the EU for 1st-line maintenance treatment of BRCA-mutated advanced ovarian cancer [AstraZeneca]










Japan becomes the first country to approve Roche’s personalised medicine Rozlytrek [Roche]











Combination Therapy with Venetoclax Approved for Chronic Lymphocytic Leukemia [NCI]











Roche wins Japan approval for personalized cancer drug Rozlytrek [Reuters]











AstraZeneca's Lynparza gets EU nod as first-line ovarian cancer maintenance treatment [Reuters]











6. LUTTE CONTRE LES CANCERS



Glioblastoma and children’s brain tumours: teams awarded £18 million Cancer Research UK Brain Tumour Awards [Cancer Research UK]