Onco Actu du 28 mai 2019

	1. BIOLOGIE
When it comes to cancer, how can DNA become its own enemy? [Institute of Cancer Research] Dr Gideon Coster recently joined the ICR to understand more about DNA replication – how it works and what happens when it goes wrong. In particular, he is looking at so-called ‘repetitive DNA sequences’, in which sequences of DNA code are repeated many times over.
	3.1.1 PRÉVENTION - TABAC - E-CIGS
E-cigarette use, flavorings may increase heart disease risk, study finds [Stanford Medicine] This study was the first to use endothelial cells derived from iPS cells to directly investigate the effect of e-liquids with and without nicotine on their viability and function. A paper describing the findings was published online May 27 in the Journal of the American College of Cardiology.
Study suggests e-cigarette flavorings may pose heart risk [AP] In laboratory dishes, they grew cells that normally line healthy human blood vessels. They exposed the cells to six different e-cigarette flavorings, testing if the flavors — and not just the nicotine — caused any effects.
Scientists Wanted: Recruited by Juul, Many Researchers Say No [NY Times] Because many researchers have spurned the company’s lucrative offers, Juul has had to rely on scientists with tobacco industry ties — further damaging the company’s credibility and making it even tougher to attract independent investigators.
	5. TRAITEMENTS
IMMUNOTARGET Registry in Advanced NSCLC With Oncogenic Driver Alterations [ESMO] Prof. Julien Mazières of the Thoracic Oncology Department, Hôpital LARREY, CHU Toulouse, Toulouse, France and colleagues, therefore concluded that immune checkpoint inhibitor should only be considered after exhaustion of targeted and standard therapies.
	6.1 OBSERVATION
Surprising number of people with pancreatic cancer may miss out on life-prolonging treatment [CBC] The study looked at 10,881 patients with a new diagnosis of advanced pancreatic cancer over an 11-year period ending in 2016 in Canada. Researchers looked at how many patients saw a medical cancer specialist (oncologist) and how many received treatment after consultation.
Cirrhosis, cancer risks higher with fatty liver - especially in diabetics [Reuters] Dr. Alazawi’s team studied data on 18 million Europeans, to investigate the odds that people with NAFLD or NASH (a worse stage of NAFLD with liver inflammation and damage) would develop cirrhosis or liver cancer.
	6.11 PATIENTS
Not if but when: After a diagnosis of brain cancer, a young dad and his family grapple with the uncertain time he has left [STAT] Since his diagnosis, he had waded into the world of cancer advocacy, spinning his circumstances into new purpose. But he and Whitney have had to balance that against enduring dreams that might go unrealized, the daily costs of living with cancer, and preserving the family life they had built.
	6.4 MÉDICO-ÉCO
Medical coding and billing: The inside story of how the sausage is made [Clear Health Costs] “It’s crazy — there’s no education for us to learn how to bill. And it’s too complex — more complex than treatment. If you have a patient who has a problem, you know what to do. But when it comes to documentation and billing, it’s not patient-friendly and it’s not provider-friendly.”
	6.7.2 APPLIS
Building bridges between cancer patients and personalized care [OICR] Krzyzanowska teamed up with the University Health Network’s Healthcare Human Factors team to explore how to improve symptom management for patients with a more personalized approach. In response to this need, they created bridges, a web-based app to facilitate remote management of chemotherapy-related side effects.