vendredi 5 avril 2019

Onco Actu du 5 avril 2019


1. BIOLOGIE



Genome-Wide Analysis Reveals New Strategies to Target Pancreatic Cancer [UCSD]











How white blood cells choose the quickest path through your body [Nature]











3.3 PRÉVENTION - VACCINS



HPV rates tumble after routine vaccination [The Guardian]











4.10 DÉP., DIAG. & PRONO. - FDA, EMA, NICE,...



FDA issues warning letter to genomics lab for illegally marketing genetic test that claims to predict patients’ responses to specific medications [FDA]











5. TRAITEMENTS



Q&A: Epigenetic Therapies for Breast Cancer [The Scientist]











5.1 TRAITEMENTS - PRÉ-CLINIQUE



Blocking epigenetic “Swiss army knife” may be a new strategy for treating colorectal cancer [Van Andel Institute]











New hope for treating childhood brain cancer [Rockefeller University]










Researchers Discover Potential Way to Hit Elusive Target in Pancreatic Cancer [NCI]











5.12 IMMUNOTHÉRAPIES



Cancer Exports Molecular ‘Saboteurs’ to Remotely Disarm Immune System [UCSF]










Cancer’s Trick for Dodging the Immune System [NY Times]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Janssen’s CAR-T gains PRIME status in Europe [PM Live]











5.2 PHARMA



Daiichi's Xospata rival pushed back by FDA as it combs through new data [Fierce Biotech]











5.2.1 PHARMA - PARTENARIATS



Myriad, AstraZeneca and Merck Expand Companion Diagnostic Partnership [Myriad]











5.2.3 PHARMA - ÉCONOMIE



Merrimack 0 for 3 as it dumps cancer drug over safety fears, axes staffers (again) [Fierce Biotech]











5.3 TRAITEMENTS - FDA, EMA, NICE...



Scott Gottlieb Says He Will Return to Conservative Think Tank After Leaving F.D.A. [NY Times]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



U.S. FDA Approves IBRANCE® (palbociclib) for the Treatment of Men with HR+, HER2- Metastatic Breast Cancer [Pfizer]











FDA expands approved use of metastatic breast cancer treatment to include male patients [FDA]










5.9.9 AACR - IMMUNOTHÉRAPIES



AACR Annual Meeting 2019: Manipulating the Immune System in Cancer Therapy [Cancer Research Catalyst]










6. LUTTE CONTRE LES CANCERS



Johns Hopkins Faculty, Staff Members Address Travails of Navigating Metastatic Cancer Survivorship in New England Journal of Medicine Perspective Piece [Johns Hopkins]










6.1 OBSERVATION



Bad Diets Are Responsible For More Deaths Than Smoking, Global Study Finds [NPR]











6.10.1 POLITIQUES (USA)



U.S. forces health company to ditch Chinese investor, in sign of heightened concern over foreign influence [STAT]











6.12 ETHIQUE



Memorial Sloan Kettering Leaders Violated Conflict-of-Interest Rules, Report Finds [NY Times]










6.2 IMPLANTS MAMMAIRES



Health Canada plans to suspend Allergan's breast implant license [Reuters]











6.7 DMP, BIG DATA & APPLIS



NHSX to mandate health tech standards [HTN]











6.7.1 IA/BIOINFORMATIQUE



In defense of the black box [Science]










6.9 CONTROVERSES



The Importance of Predefined Rules and Prespecified Statistical Analyses [JAMA]