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1. BIOLOGIE
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Genome-Wide Analysis Reveals New Strategies to Target Pancreatic Cancer [UCSD]
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In a new paper publishing in the April 4, 2019 online issue of Cell, an international team of scientists led by researchers at University of California San Diego School of Medicine employed an array of next-generation sequencing and gene-editing tools, such as CRISPR, to map the molecular dependencies —and thus vulnerabilities — of pancreatic cancer stem cells.
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How white blood cells choose the quickest path through your body [Nature]
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Immune cells inside the body need to make their way through densely packed tissues, squeezing through gaps and finding the most efficient route. During metastasis, cancer cells may make use of a similar type of locomotion. Now, experiments reveal how the cells probe different paths and use their bulky nucleus to gauge the size of gaps.
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3.3 PRÉVENTION - VACCINS
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4.10 DÉP., DIAG. & PRONO. - FDA, EMA, NICE,...
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5. TRAITEMENTS
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5.1 TRAITEMENTS - PRÉ-CLINIQUE
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New hope for treating childhood brain cancer [Rockefeller University]
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This study contributes to a growing body of research pointing to cholesterol interference as a promising new way to treat cancer. Moving forward, Phillips and his colleagues hope to develop compounds that are optimized for targeting brain cancer. As a starting point, they are studying a number of cholesterol-reducing compounds that are already on the market.
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5.12 IMMUNOTHÉRAPIES
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Cancer Exports Molecular ‘Saboteurs’ to Remotely Disarm Immune System [UCSF]
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These PD-L1–packed exosomes sprout from cancer cells and travel through the lymphatic system or bloodstream to lymph nodes, the sites where immune cells are activated to protect the body. There, the PD-L1 proteins act as itinerant molecular saboteurs, remotely disarming immune cells and preventing them from locating tumors to mount an anti-cancer offensive.
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Cancer’s Trick for Dodging the Immune System [NY Times]
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The new study is part of a growing body of research that suggests that even when tumors don’t have this PD-L1 molecule on their surfaces, they are still using the molecule to trick the immune system. Instead of appearing on the surface, the molecule is released by the tumor into the body, where it travels to immune system hubs, the lymph nodes, and tricks the cells that congregate there.
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5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES
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Janssen’s CAR-T gains PRIME status in Europe [PM Live]
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Janssen has been granted a valuable PRIME (Priority Medicines) designation from the European Medicines Agency for its CAR-T candidate for multiple myeloma, a fast-track status which could give it an advantage in the race to market.
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5.2 PHARMA
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5.2.1 PHARMA - PARTENARIATS
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5.2.3 PHARMA - ÉCONOMIE
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5.3 TRAITEMENTS - FDA, EMA, NICE...
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5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)
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5.9.9 AACR - IMMUNOTHÉRAPIES
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6. LUTTE CONTRE LES CANCERS
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6.1 OBSERVATION
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6.10.1 POLITIQUES (USA)
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6.12 ETHIQUE
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6.2 IMPLANTS MAMMAIRES
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6.7 DMP, BIG DATA & APPLIS
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NHSX to mandate health tech standards [HTN]
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NHSX has announced it wants to assemble a world-class team of technical experts to help solve some of the biggest technology challenges in health and care. Digital experts from newly formed NHSX will be embedded in national mental health and cancer teams to help clinicians and policymakers improve patient experience through the power of technology.
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6.7.1 IA/BIOINFORMATIQUE
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In defense of the black box [Science]
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Although AI thought processes can be limited, biased, or outright wrong, they are also different from human thought processes in ways that can reveal new connections and approaches. This brings us to the third case for black box systems: as tools to inspire and guide human inquiry.
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6.9 CONTROVERSES
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The Importance of Predefined Rules and Prespecified Statistical Analyses [JAMA]
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Banning statistical significance while retaining P values (or confidence intervals) will not improve numeracy and may foster statistical confusion and create problematic issues with study interpretation, a state of statistical anarchy. Uniformity in statistical rules and processes makes it easier to compare like with like and avoid having some associations and effects be more privileged than others in unwarranted ways.
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