lundi 1 avril 2019

Onco Actu du 1er avril 2019


1. BIOLOGIE



‘Jumping genes’ drive many cancers [WUSTL]











3.1.1 PRÉVENTION - TABAC - E-CIGS



Vape Nation: Vaping Is Bad, Kids [Science-Based Medicine]










4.12 BIOPSIES LIQUIDES



AstraZeneca Liquid Biopsy Comparison Publication Details Concordance Failures [Genome Web]











5.1 TRAITEMENTS - PRÉ-CLINIQUE



Mopping Up Excess Chemotherapy Drugs [The Scientist]











Researchers target metastasis in fight against cancer [University of Alberta]











5.10 TRAITEMENTS - ESSAIS



Improving the Design of Pivotal Clinical Trials [Clinical Advances in Hematology & Oncology]










5.12 IMMUNOTHÉRAPIES



Contending with Resistance in Cancer Immunotherapy [The Scientist]











5.12.8 IMMUNOTHÉRAPIES - ECONOMIE



Keytruda nabs key lung cancer nod in China. But are blockbuster sales really attainable? [Fierce Pharma]










5.2.1 PHARMA - PARTENARIATS



AstraZeneca inks ambitious $6.9B deal for Daiichi cancer therapy [Biopharma Dive]











5.2.2 PHARMA - FUSIONS & ACQUISITIONS



Bristol-Myers scores critical endorsements for its embattled Celgene merger [STAT]











Boehringer Ingelheim Enhances Oncology R&D with Novel MacroDel Delivery Technology Via Acquisition of ICD Therapeutics [Boehringer Ingelheim]











5.3 TRAITEMENTS - FDA, EMA, NICE...



Scott Gottlieb reflects on his tenure before joining the club of ex-FDA chiefs [Fierce Biotech]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



Revlimid [EMA]










5.9.4 AACR - POUMON



AACR: Chi-Med, AstraZeneca's savolitinib helps some Tagrisso-resistant EGFR lung cancer patients [Fierce Pharma]










AstraZeneca finds early-stage success with MET inhibitor in lung cancer [Biopharma Dive]











Adding the MET Inhibitor Savolitinib to Osimertinib was Beneficial for Certain Pretreated Lung Cancer Patients in TATTON Trial [AACR]











5.9.5 AACR - CAR-T



HER2-targeted CAR T-cell Therapy Safe, With Promising Antitumor Activity in Patients With Advanced Sarcoma [AACR]











Early studies hint at some potential for CAR-T therapy in solid tumors [Biopharma Dive]











Mesothelin-targeted CAR T-cell Therapy Safe, Shows Early Promise in Patients With Advanced Solid Tumors [AACR]











5.9.7 AACR - DIVERS



Use of Oral Contraceptives Protects Against Most-Fatal Types of Ovarian Cancer [Roswell Park]










5.9.9 AACR - IMMUNOTHÉRAPIES



Roche’s ipatasertib in combination with Tecentriq and chemotherapy shows promising anti-tumour activity in triple-negative breast cancer in early phase trial [Roche]











AACR: Bristol-Myers Squibb's Opdivo-Yervoy duo provokes response in rare tumors [Fierce Pharma]











Immune Checkpoint Inhibitor Combination Efficacious For Patients With High-grade Neuroendocrine Carcinoma [AACR]











The Parker Institute touts early results in pancreatic cancer trial — and a new model to accelerate drug development [STAT]










CRI-Sponsored Trial Reveals Promising Potential of Immunotherapy Combination in Metastatic Pancreatic Cancer [Cancer Research Institute]











6.1 OBSERVATION



Asbestos exposure putting lives at risk 20 years since ban [IOSH]










Asbestos still killing 5,000 Britons each year, 20 years after ban [The Telegraph]











6.6 PUBLICATIONS



The value of a journal is the community it creates, not the papers it publishes [LSE Impact Blog]











Announcing a New AACR Journal : BLOOD CANCER DISCOVERY [AACR]











Scientific integrity “a rare commodity these days:” Cancer journal makes its first retraction [Retraction Watch]