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1. BIOLOGIE
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2. ETIOLOGIE
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Scott Kelly Spent a Year in Orbit. His Body Is Not Quite the Same. [NY Times]
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Peter Campbell, a cancer biologist at the Wellcome Sanger Institute in Britain who was not involved in the new study, said scientists can’t predict what the extra mutations will mean for Mr. Kelly’s health. “It is hard to be sure, but I believe those sorts of numbers would be associated with a moderate increase in cancer risk,” he said.
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2.6 ETIOLOGIE - ENVIRONNEMENT
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3.1 PRÉVENTION - TABAC
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4.1 DÉP., DIAG. & PRONO. - PROSTATE
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4.3 DÉP., DIAG. & PRONO. - INDUSTRIELS
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5.12.6 IMMUNOTHÉRAPIES - AMM
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FDA expands pembrolizumab indication for first-line treatment of NSCLC (TPS ≥1%) [FDA]
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Approval was based on KEYNOTE‑042 (NCT02220894), a randomized, multicenter, open-label, active-controlled trial conducted in 1274 patients with stage III or IV NSCLC who had not received prior systemic treatment for metastatic NSCLC and whose tumors expressed PD-L1 (TPS ≥1%). PD-L1 expression was determined by an immunohistochemistry assay using the PD-L1 IHC 22C3 pharmDx Kit.
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5.12.8 IMMUNOTHÉRAPIES - ECONOMIE
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5.3 TRAITEMENTS - FDA, EMA, NICE...
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Added therapeutic benefit and drug licensing [Nature Reviews Drug Discovery]
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One aspect of the ongoing debate about drug pricing is the added therapeutic benefit of new drugs compared with existing — and potentially cheaper — therapies. Here, we discuss the merits and pitfalls of proposals that are being discussed with regard to the role of regulatory agencies in establishing added therapeutic benefit.
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5.6.4 ESMO - POUMON
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5.9 AACR
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6.1 OBSERVATION
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6.12 ETHIQUE
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6.5 MÉDECINES ALTERNATIVES/COMPLÉMENTAIRES
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6.6 PUBLICATIONS
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6.7.3 DMP
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Electronic health records are still waiting to be transformed [STAT]
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In addition to highlighting their inability to share information across proprietary platforms, as well as the fact that physicians report spending more time than ever on data entry rather than interacting with patients, the in-depth investigation uncovered thousands of incidents in which errors caused by faulty electronic health records harmed patients.
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