jeudi 11 avril 2019

Onco Actu du 11 avril 2019


1. BIOLOGIE



Cancer: central role of cell ‘skeleton’ discovered [Cnrs]











1.1 BIOLOGIE - GÈNES



Why do certain faulty genes only cause cancer in some parts of the body? [Cancer Research UK]










1.4 BIOLOGIE - TECHNOS



Scientists use DNA-editing tool CRISPR to catalogue cancer’s weaknesses [Cancer Research UK]











Scientists use editing tool to identify key cancer genes [The Guardian]











Loss of a DNA repair system creates a unique vulnerability in many cancer types [Broad Institute]










'Dismantling cancer' reveals weak spots [BBC News]











3.1.1 PRÉVENTION - TABAC - E-CIGS



Exclusive: India trade ministry says no legal basis to ban e-cigarette imports - document [Reuters]











3.3 PRÉVENTION - VACCINS



Childhood HPV vaccination 'profoundly' cuts cervical disease in young women [Reuters]











4.12 BIOPSIES LIQUIDES



Natera Announces Plans to Commercialize Tumor Whole Exome Sequencing from Plasma [Natera]











5.10 TRAITEMENTS - ESSAIS



High-dose vitamin D shows benefit in patients with advanced colorectal cancer [Dana-Farber Cancer Institute]











5.2 PHARMA



Unblinded: Hervé​ Hoppenot on solving Incyte's 'single asset syndrome' [Biopharma Dive]











5.2.1 PHARMA - PARTENARIATS



Shanghai Miracogen taps Synaffix's antibody-drug conjugate tech in a deal worth up to $125M [Fierce Biotech]











5.2.3 PHARMA - ÉCONOMIE



Faced by R&D setbacks and questionable gains, Gilead’s new CEO’s first move is to reach for the ax [EndPoints]











5.4 TRAITEMENTS - ECONOMIE



Novartis' Kisqali takes step back in heated market after NICE no vote [Fierce Pharma]











Breast cancer drug combo gets initial ‘no’ for NHS in England [Cancer Research UK]











5.6.4 ESMO - POUMON



PROs Were Consistent with the ITT Population Across PD-L1 Subgroups in Patients with Stage III NSCLC Receiving Durvalumab or Placebo [ESMO]











5.9 AACR



AACR Annual Meeting 2019: Global Burden of Pathogen-related Cancers [Cancer Research Catalyst]










6.3 ASSOCIATIONS/FONDATIONS



Saving Lives One CX At A Time: American Cancer Society Modernizes Website [Forbes]











6.4 MÉDICO-ÉCO



Treating cancer patients who smoke may cost extra $3.4 billion each year [Reuters]











6.7 DMP, BIG DATA & APPLIS



Foundation Medicine and Flatiron Health Publish Validation of Clinico-Genomic Database as a Platform to Advance Oncology Therapeutics Development and Personalized Cancer Care [Foundation Medicine]










Foundation Medicine, Flatiron Health Publish Clinical Validity of Clinico-Genomics Database [Genome Web]











6.9 CONTROVERSES



Exact replication: Foundation of science or game of chance? [PLoS Biology]