jeudi 7 mars 2019

Onco Actu du 7 mars 2019


1. BIOLOGIE



Cancer Most Frequently Spreads to the Liver. Here’s Why. [Penn Medicine]










1.4 BIOLOGIE - TECHNOS



Interview with Dr. Matthew H. Porteus on therapeutic editing of the human genome. [NEJM]











4.12 BIOPSIES LIQUIDES



Microfluidic Circulating Tumor Cell Capture Tech Shows Promise in Proof-of-Concept Study [Genome Web]











4.9 DÉP., DIAG. & PRONO. - SEIN



Study finds robots can detect breast cancer as well as radiologists [EurekAlert!]











5.1 TRAITEMENTS - PRÉ-CLINIQUE



Starving Cancer Stem Cells Could Be the Trick to Treating Glioblastoma, Study Finds [Memorial Sloan-Kettering Cancer Center]










5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES



Genetically engineered immune cells wipe out lupus in mice [Science]











5.2.2 PHARMA - FUSIONS & ACQUISITIONS



Another influential voice takes Bristol-Myers’ top execs to task as they scramble to shore up the big Celgene buyout [EndPoints]











5.2.3 PHARMA - ÉCONOMIE



Joining AI Drug Discovery Race, Erasca Adds $22M For Cancer Work [Xconomy]











Following key late-stage advances, BeiGene puts down $10M to get some discovery projects rolling at Ambrx [EndPoints]











5.3 TRAITEMENTS - FDA, EMA, NICE...



A New FDA Commissioner, Suddenly [In The Pipeline]











U.S. FDA chief tough on e-cigarettes steps down abruptly [Reuters]











5.3.4 TRAITEMENTS - AMM (FDA, EMA,...)



EMA Recommends Approval of Pazenir for the Treatment of Metastatic Breast Cancer and NSCLC [ESMO]











5.4 TRAITEMENTS - ECONOMIE



NICE evidence request for Blincyto for acute lymphoblastic leukaemia [Pharma Times]











6. LUTTE CONTRE LES CANCERS



Why is it so hard to turn fundamental scientific knowledge into effective cures and how can we do this better in the future? [BACR]











6.1 OBSERVATION



Cancer death rate higher for patients with mental health history [Cancer Research UK]











6.10 POLITIQUES



W.H.O. Chief Plans to Reorganize a Vast Bureaucracy [NY Times]











WHO chief unveils reforms, with more science, apps and an academy [Reuters]










WHO unveils sweeping reforms in drive towards “triple billion” targets [WHO]











6.10.1 POLITIQUES (USA)



With Gottlieb’s resignation, the Trump administration loses its backroom whisperer on Capitol Hill [STAT]











6.11 PATIENTS



Alex Trebek Is Diagnosed With Advanced Pancreatic Cancer–And We Are Reminded Of The Strength And Dignity Those With Cancer Offer To Others, Every Day [Dr. Len]











6.12 ETHIQUE



Jennifer Doudna Is Pioneering the Science — and Ethics — of Gene Editing [Rolling Stone]











China to tighten rules on gene editing in humans [Nature]











6.4 MÉDICO-ÉCO



NHS cancer centre loses scanning contract to private firm [The Guardian]











6.6 PUBLICATIONS



A report about Plan S’s potential effects on journals marks a busy week for the open-access movement [Science]











Tracker is a boon for innovation in peer review [Nature]











6.7 DMP, BIG DATA & APPLIS



What’s scary, and appealing, about real-world evidence [STAT]










6.7.1 IA/BIOINFORMATIQUE



The Life-Threatening Consequences of Overhyping AI [Wired]











Policies designed for drugs won’t work for AI [Nature]










6.7.3 DMP



Health data alone doesn’t account for much. We need better ways to extract its value [STAT]