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1. BIOLOGIE
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Sticking together helps cancer to spread [Nature]
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When cancer spreads, this metastatic stage of the disease is usually lethal. An analysis of immune cells that cluster with tumour cells in the bloodstream illuminates a partnership that might aid metastasis.
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2.6 ETIOLOGIE - ENVIRONNEMENT
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2.7 ETIOLOGIE - OBÉSITÉ
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4. DÉPISTAGE, DIAGNOSTIC ET PRONOSTIC
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Doctors debate whether to stop calling low-risk tumors 'cancer' [Reuters]
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Esserman argues that given how widely tumors vary, both in form and severity, it is ethically unsound to frighten patients by telling them they have cancer when in fact they don’t have a risky prognosis. But Dr. Murali Varma, writing in the same issue of The BMJ in a counterpoint to Esserman, argues that renaming certain cancers is likely to be confusing and proposes education as a better way forward.
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4.2 DÉP., DIAG. & PRONO. - GÉNOME
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4.9 DÉP., DIAG. & PRONO. - SEIN
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5. TRAITEMENTS
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5.1 TRAITEMENTS - PRÉ-CLINIQUE
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Brain Tumor 'Pied Piper' Device Gains Breakthrough Status [Duke University]
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Dubbed the Tumor Monorail, the device mimics the physical properties of the brain’s white matter to entice aggressive tumors to migrate toward the exterior of the brain, where the migrating cells can be collected and removed. The purpose of the device is not to destroy the tumor, but to halt its lethal spread, making the disease more of a condition to manage than a death sentence.
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5.10 TRAITEMENTS - ESSAIS
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MacroGenics breast cancer drug tops Herceptin in late-stage trial [Biopharma Dive]
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The results suggest margetuximab could be an option for patients who may be close to exhausting other therapies. All the patients in the study had previously been treated with Herceptin (trastuzumab) and Perjeta (pertuzumab), and about 90% had received Kadcyla (ado-trastuzumab emtansine) as well. All three drugs are sold by Roche.
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5.12 IMMUNOTHÉRAPIES
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5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES
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5.2 PHARMA
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6. LUTTE CONTRE LES CANCERS
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'Watchful waiting' is best approach for most ovarian cysts, study finds [The Telegraph]
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The new research followed nearly 2,000 women as they were scanned in the years after a benign cyst diagnosis. Overall, in 80 per cent of cases the cyst resolved or did not need intervention, the study found. Twenty per cent of cysts disappeared entirely, while 16 per cent of cases underwent surgery. In total, 12 women were subsequently diagnosed with ovarian cancer - suggesting a risk of 0.4 per cent.
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6.10.1 POLITIQUES (USA)
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6.2 IMPLANTS MAMMAIRES
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6.6 PUBLICATIONS
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We need to talk about systematic fraud [Nature]
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I’m not alone in my suspicions that dubiously produced papers are getting published. Informatician Cyril Labbé at Grenoble Alps University in France and I have developed a tool, Seek & Blastn, to identify such papers on the basis of wrongly identified nucleotide sequences. So far, our work has uncovered dozens of papers and resulted in 17 retractions, with several investigations pending.
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Thousands of scientists run up against Elsevier’s paywall [Nature]
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Researchers at German institutions that have let their Elsevier subscriptions lapse while negotiating a new deal are hitting the paywall for the publisher’s most recent articles around 10,000 times a day, according to Elsevier — which publishes more than 400,000 papers each year.
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6.7.2 APPLIS
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Slack telegraphs moves into healthcare as it gears up for IPO: report [Fierce Biotech]
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If it dives into the healthcare space, Slack will go up against offerings such as the clinic-focused startup Stitch—with its HIPAA-compliant messaging channels organized around individual patients—as well as Microsoft’s Teams app, which began adding features such as secure care coordination, image annotation and electronic health record integration last year.
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