jeudi 21 février 2019

Onco Actu du 21 février 2019


1.4 BIOLOGIE - TECHNOS




Beyond Generations: My Vocabulary for Sequencing Tech [Omics! Omics!]











3.1 PRÉVENTION - TABAC




FDA advances framework for enabling the study of new tobacco products as part of the agency’s ongoing commitment to improve the efficiency and effectiveness of tobacco product regulation [FDA]











3.3 PRÉVENTION - VACCINS




Cervical cancer 'could become a thing of the past' [NHS Choices]











Preventing cervical cancer: how a screening switch and HPV vaccination should cut cancer rates [Cancer Research UK]











4.10 DÉP., DIAG. & PRONO. - FDA, EMA, NICE,...




FDA Draft Guidance on Broader Labeling for Oncology Companion Diagnostics Draws Mixed Reactions [RAPS]












Balancing Benefit and Risk in Medical Device Regulation [FDA Law Blog]











4.2 DÉP., DIAG. & PRONO. - GÉNOME




New recommendations say not all women need genetic testing for cancer. Critics say it could cost lives [CNN]












BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing [USPSTF]










5.1 TRAITEMENTS - PRÉ-CLINIQUE




Dormant Tumor Cells Can Be Sensitized to Chemotherapy [NCI]











5.10 TRAITEMENTS - ESSAIS




Novel antibody-drug conjugate shows promise against metastatic triple-negative breast cancer [Mass. General Hospital]











Trial publishes data on preventing blood clots in cancer patients [ecancer News]












Immunomedics Announces Publication of Triple-Negative Breast Cancer Data with Sacituzumab Govitecan in the New England Journal Of Medicine [Immunomedics]












New “Smart Drug” Shows Promise for Metastatic Triple-Negative Breast Cancer [Columbia University]











5.12 IMMUNOTHÉRAPIES




Study finds melanoma brain metastases are immunosuppressive with treatment-resistant metabolism [MD Anderson Cancer Center]












Study Finds Way to Potentially Improve Immunotherapy for Cancer [Cedars-Sinai]











5.12.1 IMMUNOTHÉRAPIES - PARTENARIATS




Torque Announces Clinical Trial Collaboration with Merck [Torque]











5.12.2 IMMUNOTHÉRAPIES - CAR-T, THÉRAPIES CELLULAIRES




Allogene Therapeutics to build out facility for allogeneic CAR T treatments [Fierce Pharma]












Allogene Therapeutics Enters Lease to Build Manufacturing Facility to Develop and Commercialize Allogeneic CAR T (AlloCAR T™) Therapies [Allogene]












Retraction Note: A homing system targets therapeutic T cells to brain cancer [Nature]












Nature Retracts Paper on Delivery System for CAR T Immunotherapy [The Scientist]










5.12.4 IMMUNOTHÉRAPIES - ESSAIS




Merck's Keytruda hits the skids in pivotal trial, putting its liver cancer nod at risk [Fierce Pharma]












After accelerated approval, Merck's Keytruda fails in liver cancer study [Biopharma Dive]











5.12.5 IMMUNOTHÉRAPIES - PHARMA




FDA Grants Priority Review to Merck’s Supplemental Biologics License Application for KEYTRUDA® (pembrolizumab) Monotherapy for Third-Line Treatment of Patients with Advanced Small Cell Lung Cancer (SCLC) [Merck]











5.2 PHARMA




Turbulent times for Xencor as FDA slaps hold on AML bispecific [Fierce Biotech]












Agios Announces FDA Acceptance of Supplemental New Drug Application for TIBSOVO® (ivosidenib) for the Treatment of Patients with Newly Diagnosed Acute Myeloid Leukemia with an IDH1 Mutation Not Eligible for Standard Therapy [Agios]












Xencor Announces Partial Clinical Hold on Phase 1 Study of XmAb14045 [Xencor]












Deaths spur partial hold for Xencor’s CD3 bispecific for leukemia, partnered with Novartis in $2.5B deal [EndPoints]











5.4 TRAITEMENTS - ECONOMIE




Drug Prices Based On Success Could Speed Up Cancer Patients' Treatment [Cancer Research UK]










6. LUTTE CONTRE LES CANCERS




Report Says Health Systems Are Key to Improving Cancer Outcomes in the United States [ACS]












Minimizing the burden of cancer in the United States: Goals for a high‐performing health care system [CA: A Cancer Journal for Clinicians]











6.10 POLITIQUES




A new law was supposed to protect South Africans' privacy. It may block important research instead [Science]











6.2 IMPLANTS MAMMAIRES




Breast implant associated-anaplastic large cell lymphoma (BIA-ALCL) – updated information [Swissmedic]











6.6 PUBLICATIONS




Large Teams and Small Ones in Science [In The Pipeline]










6.7 DMP, BIG DATA & APPLIS




ASCO Seeks Applicants for Research Grants to Use Data from CancerLinQ Discovery [ASCO]












NHSX: new joint organisation for digital, data and technology [Gov.uk]










6.7.1 IA/BIOINFORMATIQUE




New AI able to identify and predict the development of cancer symptom clusters [University of Surrey]











6.9 CONTROVERSES




Facebook’s controversies now extend to health and medicine issues [STAT]












U.S. Investigating Johnson & Johnson Over Baby Powder’s Safety [NY Times]