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1. BIOLOGIE
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From microfluidics to metastasis [MIT]
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The system, described in the Proceedings of the National Academy of Sciences the week of Jan. 21, diverts blood to a microfluidic cell-sorting chip that extracts individual CTCs before returning the blood back to an awake mouse.
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1.4 BIOLOGIE - TECHNOS
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4.2 DÉP., DIAG. & PRONO. - GÉNOME
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5.1 TRAITEMENTS - PRÉ-CLINIQUE
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Helping give hope to patients with rare chordoma cancers [Institute of Cancer Research]
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The study team set out to identify potential therapeutic targets by taking two complementary, large-scale screening approaches. The first was to use CRISPR-Cas9 technology to genetically knock out individual genes across the chordoma genome, and the second was to test a library of small-molecule chemicals for activity against chordoma cell lines.
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5.12.5 IMMUNOTHÉRAPIES - PHARMA
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5.2 PHARMA
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5.4 TRAITEMENTS - ECONOMIE
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6.1 OBSERVATION
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6.11 PATIENTS
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6.4 MÉDICO-ÉCO
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6.5 MÉDECINES ALTERNATIVES/COMPLÉMENTAIRES
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6.7.1 IA/BIOINFORMATIQUE
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Medical AI Safety: Doing it wrong. [Luke Oakden-Rayner]
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If it wasn’t for the slow, statistical nature of the problems with CAD (computer aided diagnosis), occurring over decades and measured in calculated lives rather than visible people, we might call breast CAD a medical tragedy. What would happen to medical AI as a sector if something like this occurred because we had not been as diligent as we knew we should be?
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6.8 COMMUNICATION
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When Cancer Meets the Internet [NY Times]
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As a specialist in breast cancer, Dr. Schapira has treated women who decline postoperative therapy with a drug like tamoxifen or an aromatase inhibitor because they read on the web that the treatments are harmful, despite extensive studies showing they can help prevent a breast cancer recurrence. “The conviction about harm is an emotional reaction, and it’s very difficult for a doctor to talk facts through emotions,” she said.
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