mardi 11 décembre 2018

Onco Actu du 11 décembre 2018

1. Biologie

The cells that help cancer drugs to cloud the mind [Nature]

2. Etiologie

Transplanted organs gave patients cancer [BBC News]

4.2 Dép., diag. & prono. - Génome

Breast cancer testing guidelines out of date, missing genetic screening, says study [CNN]

5. Traitements

HER2 mutations can cause treatment resistance in metastatic ER-positive breast cancer [Broad Institute]

5.12 Immunothérapies

An impassioned conversation on Impassion130: Atezolizumab in combination with nab-paclitaxel in metastatic triple negative breast cancer [ecancer news]

5.12.2 Immunothérapies - CAR-T, thérapies cellulaires

Carl June, MD, Talks CAR T-cell Therapies at AACR Conference [Cancer Research Catalyst]

5.12.4 Immunothérapies - Essais

MacroGenics Announces Partial Clinical Hold on MGD009 Phase 1 Studies [MacroGenics]

MacroGenics halts trials of cancer drug after FDA partial hold [FierceBiotech]

FDA slaps partial hold on MacroGenics for bispecific cancer trials as liver tox spurs safety fears [EndPoints]

5.12.5 Immunothérapies - Pharma

Gritstone ramps up bispecifics with new antibody therapeutics chief [FierceBiotech]

Gilead, looking for cancer sales, swipes Roche pharma chief O'Day for CEO post [FiercePharma]

5.12.6 Immunothérapies - AMM

Withdrawal of Application for a Change to the EU Marketing Authorisation for Atezolizumab [ESMO]

5.2.1 Pharma - Partenariats

AstraZeneca, Cancer Research UK set up genomics hub to fight uphill battle against cancer [EndPoints]

Cancer Research UK and AstraZeneca launch world class functional genomics centre [Cancer Research UK]

5.4 Traitements - Economie

How to Cut Drug Prices: Experts Weigh In [NY Times]


SABCS 2018 Features Molecular Diagnostics Research [Genome Web]

6.1 Observation

Delivering a baby increases - then lowers - risk of breast cancer: study [Reuters]

Giving birth increases women’s breast cancer risk in the short term [Institute of Cancer Research]

6.10 Politiques

Brexit 'no deal' could mean 6 months of disruption for pharma [BiopharmaDive]

6.12 Ethique

We Have Ways To Stop Rogue Scientists. They Don’t Always Work. [FiveThirtyEight]

6.14 Prix Nobel

Allison receives Nobel Prize today in Sweden for immunotherapy innovation [TMC News]