vendredi 28 septembre 2018

Onco Actu du 28 septembre 2018

1. Biologie

Some breast cancers have a pause button [Garvan Institute]

How a sleeping cancer awakens and metastasizes [Cold Spring Harbor Lab]

2.10 Etiologie - Alcool

Moderate Alcohol And Breast Cancer: Real Epidemiology Or Just Statistical Correlation? [Science 2.0]

2.6 Etiologie - Environnement

Glyphosate [Australian Pesticides and Veterinary Medicines Authority]

Australia: ‘No grounds’ to ban Roundup, despite glyphosate-cancer controversy [Genetic Literacy Project]

5. Traitements

Brain cancer [Nature Outlook]

5.1 Traitements - Pré-clinique

‘Star Trek’ protein could be key to repurposing EGFR lung cancer drugs in leukemia [FierceBiotech]

5.10 Traitements - Essais

Shrinking oncology phase I clinical trials: If the drug is a breakthrough, why would you ever want to utilize the maximally tolerated dose? [The Cancer Letter]

Clinical Trials—We Get What We Pay For [JAMA Internal Medicine]

5.12.1 Immunothérapies - partenariats

Cellular Biomedicine Group Enters Into Strategic Licensing and Collaboration Agreement with a Global Leader in CAR-T Cell Therapy for Patients in China [CMBG]

5.12.10 Immunothérapies - Fusions et acquisitions

Tusk Therapeutics to be acquired by Roche [Tusk]

Roche scoops up a Treg player for the I/O team, plucking 1 drug and spinning off a 2nd into a new biotech [EndPoints]

5.12.2 Immunothérapies - CAR-T, thérapies cellulaires

Genscript rebounds on HKEX with staunch defense of Legend Biotech’s CAR-T data integrity [EndPoints]

Scathing short attack from an obscure source accuses Nanjing Legend of manipulating CAR-T data — Genscript shares nosedive [EndPoints]

5.12.3 Immunothérapies-combinaisons

Vaccine, anti-PD1 drug show promise against incurable HPV-related cancers [MD Anderson Cancer Center]

5.12.5 Immunothérapies - Pharma

KSQ grabs $80M to move T-cell treatment for PD-1 resistance into the clinic [FierceBiotech]

Akrevia Launches with $30M for Next-Gen Cancer Immunotherapy [Xconomy]

F-Prime, Atlas lead cancer startup Akrevia to $30M A round [FierceBiotech]

5.2.1 Pharma - Partenariats

J&J has decided — pharma giant dumps its development deal on Geron’s imetelstat, shattering shares [EndPoints]

5.3.4 Traitements - AMM (FDA, EMA,...)

Pfizer nabs fast OK for a new frontline lung cancer drug as pharma giant shows off its new R&D strategy [EndPoints]

U.S. FDA Approves VIZIMPRO® (dacomitinib) for the First-Line Treatment of Patients with EGFR-Mutated Metastatic Non-Small Cell Lung Cancer [Pfizer]

Pfizer's lung cancer drug gets FDA approval [Reuters]

6. Lutte contre les cancers

Global drive to tackle huge regional disparities in childhood cancer survival launched [The Telegraph]

6.1 Observation

Clinical Trial Participation and Treatment Duration May Influence Risk of Relapse in Adolescent and Young Adult Leukemia Patients [AACR]

6.10 Politiques

France seeks slim rise to research budget amid spending cuts [Nature]

6.10.1 Politiques (USA)

ASCO Praises Congress for Continuing to Invest in Federal Research [ASCO]

6.3 Associations/Fondations

Breast cancer charity demands action to avert rise in deaths [The Guardian]