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1. Biologie
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Cancer Cells Fuse with Immune Cells in Human Patients [The Scientist]
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The
hybrid cells had a greater ability to migrate and invade in vitro
compared to the unfused cancer cells, and when injected into mice, they
more readily formed metastases compared to their nonhybrid cancer cell
line counterparts. The researchers also observed spontaneous hybrid
cells in mice injected with melanoma cells.
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2. Etiologie
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2.10 Etiologie - Alcool
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2.5 Etiologie - Gènes
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3.1.1 Prévention - Tabac - e-cigs
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4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
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Blueprint for Breakthroughs - Charting the Course for Precision Medicine [FDA]
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As
clinical testing gets more and more sophisticated, we need to make
certain that we have the right regulatory framework in place to ensure
that these new clinical tests—including ones that we cannot even
envision today—are accurate, reliable, and safe. And that these tests
are made accessible to patients as soon as possible.
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4.12 Biopsies liquides
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Epic Sciences Raises $52M to Expand Cancer Diagnostic Portfolio [Xconomy]
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The
San Diego-based company, which announced the close of the Series E
round Wednesday, said it will use the proceeds to create additional
blood tests, often referred to as liquid biopsies, to help guide
clinicians in selecting the best course of treatment for patients who
have been diagnosed with cancer.
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4.2 Dép., diag. & prono. - Génome
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5.10 Traitements - Essais
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5.12.10 Immunothérapies - Fusions et acquisitions
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5.12.2 Immunothérapies - CAR-T, thérapies cellulaires
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A Young Man's Experiment With A 'Living Drug' For Leukemia [NPR]
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The
cancer has disappeared from parts of Reid's body, including his bone
marrow. Also, the genetically modified immune cells are still evident in
his body, she says, so they could continue to "attack the leukemia."
That's the good news. But the pain Reid was struggling with earlier in
the week turns out to have been an indication that in other areas his
disease has worsened.
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5.12.3 Immunothérapies-combinaisons
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Viruses show new promise in treating cancer [Institute of Cancer Research]
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Currently,
a number of viruses are being tested in clinical trials, but only one
virus has been approved for general use, by injection directly to the
tumour. The researchers hope that this study will help us gain a better
understanding of how virus therapies work, so that they can be used in
combination with other immunotherapies in future.
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5.12.5 Immunothérapies - Pharma
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Roche CEO Refuses to Cede Cancer's Hottest New Field to Merck [Bloomberg]
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Merck’s
immune therapy Keytruda has dominated the market, with analysts
predicting it will deliver more than $10 billion in annual sales by
2020. Roche still believes it can be a leader in the field of drugs
designed to unleash the body’s immune system against tumors, with
positive results for its own contender Tecentriq coming at two
conferences this fall.
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5.3 Traitements - FDA, EMA, NICE...
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Update on review of valsartan medicines [EMA]
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In
line with EMA’s previous assessment, the life-time risk of cancer is
considered low and is estimated to be in the order of 1 in 5,000 for an
adult patient who had taken an affected valsartan medicine at the
highest dose (320 mg) every day from July 2012 to July 2018.
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5.3.4 Traitements - AMM (FDA, EMA,...)
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5.5 ASCO
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6.1 Observation
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Cancer waiting times 'at worst level ever' in England [BBC News]
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In
July, 78.2% were seen in that timeframe, the worst performance since
records began in October 2009. It means more than 3,000 people waited
longer than two months for treatment to begin. The target for the NHS is
85%, which was last hit in December 2015. The target is also being
missed elsewhere in the UK.
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6.12 Ethique
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6.5 Médecines alternatives/complémentaires
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Crowdfunded cancer treatments - do they work? [BBC News]
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The
crowdfunding figures were collected by the Good Thinking Society, a
charity that promotes scientific thinking. The society's project
director, Michael Marshall, said: "Many proposals refer to specific
drugs that have been discredited, extreme dietary regimes, intravenous
vitamin C, alkaline therapy and other alternative treatments."
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6.6 Publications
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6.9 Controverses
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