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1. Biologie
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1.4 Biologie - Technos
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2. Etiologie
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2.6 Etiologie - Environnement
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3.1.1 Prévention - Tabac - e-cigs
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4. Dépistage, diagnostic et pronostic
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4.11 Dép., diag. & prono. - Ovaire
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4.2 Dép., diag. & prono. - Génome
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Study cracks open the secrets of the cancer-causing BRCA1 gene [STAT]
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The
NCI’s Chanock was more cautious. “It might be tempting to make
immediate use” of the information to interpret puzzling variants found
when women undergo BRCA tests, he wrote, but it “should not be used as
the basis for medical advice — at least until the approach has been
clinically validated.”
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5.10 Traitements - Essais
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5.12 Immunothérapies
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Predicting response to immunotherapy [NIH]
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Three
independent research teams recently reported developing ways to predict
which melanoma patients are most likely to respond to checkpoint
therapy. The work was funded in part by several NIH components. Two
papers were published in Nature Medicine on August 20, 2018, and another
in Nature on August 8, 2018.
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5.12.5 Immunothérapies - Pharma
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5.2.3 Pharma - économie
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5.3 Traitements - FDA, EMA, NICE...
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5.4 Traitements - Economie
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The Curious Case Of Gleevec Pricing [Forbes]
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What
is atypical is the fact that generic imatinib's list price has remained
stubbornly high. In late 2017, almost two years after its patent
expiration a month’s supply of branded Gleevec was priced at around
$9,000, while the cost of generic imatinib was about $8,000. This is
both puzzling and troubling, and appears to suggest that the pricing
model for specialty generics differs from traditional generics.
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5.9 AACR
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6. Lutte contre les cancers
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To The Last Drop [Journal of Clinical Oncology]
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For
most of us, at some point in our careers, our job can be dangerous.
There is danger when the weight of our words threatens to crush us as
they fill the room. There is threat when the situational burdens become
too entrenched and the existential crisis too wide to cross without a
net. It is not a job for the faint of heart, the frail of spirit, or the
fragile of psyche.
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6.1 Observation
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6.10 Politiques
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Sixteen EU Member States Sign the Genomics Declaration [ESMO]
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The
Declaration on linking genomic databases across borders was originally
launched on 10 April 2018. It has been signed since then by Bulgaria,
the Czech Republic, Cyprus, Estonia, Finland, Italy, Lithuania,
Luxembourg, Malta, Portugal, Slovenia, Spain, Sweden and the UK. Croatia
has also committed to join this list.
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6.5 Médecines alternatives/complémentaires
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Is cancer fundraising fuelling quackery? [BMJ]
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Crowdfunding
sites are helping people with advanced cancer spend thousands of pounds
on unproved and alternative treatments. Melanie Newman examines calls
to help ensure patients and their donors are not being exploited.
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6.6 Publications
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Scientific publishing: How much is too much? [Stanford Medicine]
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It's
important to be fair and transparent with how credit and rewards are
allocated. We want to reward the most energetic and the most creative,
not the most manipulative, politically savvy or coercive. I trust that
these hyperprolific authors include some of the best scientists in the
world — but they may also include some that passed this threshold for
reasons other than excellence.
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6.7 DMP, Big Data & applis
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With OneOncology, Flatiron and Cancer Docs Aim to Boost Community Care [Xconomy]
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The
company brings together doctors and patients from these three
practices, and connects them with the help of the cancer-specific
electronic health record software developed by Flatiron Health. For
Flatiron, a high-flying New York startup that Roche bought for $1.9
billion in February, OneOncology represents a way to acquire more
patient data and customers for its EHR system.
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