mardi 11 septembre 2018

Onco Actu du 11 septembre 2018

1. Biologie

Study links BAP1 protein to tumor suppression in kidney, eye, bile duct and mesothelioma cancers [MD Anderson Cancer Center]

2. Etiologie

Study links widely-used drug azathioprine to skin cancers [Queen Mary University of London]

3.1 Prévention - Tabac

Oh, How the Tables Have Turned: Court Requires FDA to Follow Law Requiring Graphic Warnings on Cigarettes [FDA Law Blog]

4. Dépistage, diagnostic et pronostic

Screening: How overdiagnosis and other harms can undermine the benefits [HealthNewsReview]

The trouble with health statistics [Cancer World]

5.12.2 Immunothérapies - CAR-T, thérapies cellulaires

Analyst offers Amgen a boost for its rival anti-BCMA BiTE, blemishing GSK as well as CAR-T rivals Celgene and bluebird [EndPoints]

5.12.5 Immunothérapies - Pharma

OncoResponse Nabs $40M for Cancer Drugs Based On Survivors’ Antibodies [Xconomy]

Focusing on the tumor microenvironment, Oncoresponse garners $40 million for the next stage of the R&D journey [EndPoints]

5.12.6 Immunothérapies - AMM

European Commission Approves Merck’s KEYTRUDA® (pembrolizumab) in Combination with Pemetrexed and Platinum Chemotherapy for the First-Line Treatment of Patients with Metastatic Nonsquamous NSCLC, with No EGFR or ALK Genomic Tumor Aberrations [Merck]

Merck's Keytruda clocks up new win as EU approves chemo cocktail [Reuters]

5.12.8 Immunothérapies - Economie

BMS' Opdivo fails to win over NICE as adjuvant melanoma therapy [Pharmafile]

5.2 Pharma

Glythera rebrands as Iksuda, pledging to solve ADC problems [FierceBiotech]

5.2.3 Pharma - économie

Is the pharma business model ready for precision medicine? [EndPoints]

5.6 ESMO

Following the tumour DNA trail to crack the secrets of personalised medicine [ESMO]

6. Lutte contre les cancers

Linguistic analysis reveals the hidden details of research grant proposal peer review reports [LSE Impact Blog]

6.10 Politiques

U.K. health minister blasts 'profiteering' pharma for trying to 'rip off taxpayers' [FiercePharma]

6.12 Ethique

How To Really Take Medical Conflicts Of Interest Seriously [Forbes]

José Baselga: “I take responsibility for failing to make appropriate disclosures” [The Cancer Letter]

A star cancer scientist failed to disclose industry payments over the years — does that matter so much? [EndPoints]

6.5 Médecines alternatives/complémentaires

Acupuncture versus breast cancer treatment-induced joint pain: Spinning another essentially negative study [Science-Based Medicine]

6.6 Publications

How AI technology can tame the scientific literature [Nature]

Peer reviewers unmasked: largest global survey reveals trends [Nature]

6.9 Controverses

Appeals court hands Broad Institute a win in CRISPR patent feud [FierceBiotech]

U.S. Court Affirms Broad’s CRISPR Patent; No Word of Berkeley Appeal [Xconomy]