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1. Biologie
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Exosomes May Help Tumors Evade Immune System [NCI]
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The
researchers likened the PD-L1-studded exosomes to a fleet of drones
engaged in preemptive strikes, moving throughout the body to thwart an
antitumor attack before immune cells—namely those known as cytotoxic T
cells—ever have a chance to reach the tumor.
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3.1.1 Prévention - Tabac - e-cigs
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4.1 Dép., diag. & prono. - Prostate
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Researchers Identify Pitfall in Popular Prostate Cancer PET Imaging Method [SNMI]
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Prostate-specific
membrane antigen (PSMA) positron emission tomography (PET) imaging has
become a popular method for determining the stage of a patient’s
prostate cancer. However, researchers have identified a major pitfall in
this imaging technique and are cautioning medical professionals to be
aware of the potential for misdiagnosis when relying solely on PSMA PET.
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4.2 Dép., diag. & prono. - Génome
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4.9 Dép., diag. & prono. - Sein
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Scientists develop new way to identify breast cancer tumors [USC]
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Aided
by machine learning, the researchers taught a computer to rapidly sort
images of breast tumors to identify which ones had estrogen receptors, a
key to determining prognosis and treatment options. That’s a big step
forward from microscopes and cell biopsies in use for more than a
century, according to the scientists.
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5.12 Immunothérapies
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Immunotherapy May Be Efficacious in Patients With HIV-associated Kaposi’s Sarcoma [AACR]
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Galanina
and colleagues analyzed data from nine men with Kaposi’s sarcoma
treated with anti-PD-1 immune checkpoint inhibitors at Moores Cancer
Center between August 2013 and December 2017. All patients had received
retroviral therapy and a median of one prior line of treatment for
Kaposi’s sarcoma. Eight patients were treated with nivolumab (Opdivo),
while one patient was treated with pembrolizumab (Keytruda).
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5.2 Pharma
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6. Lutte contre les cancers
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Jennifer Doudna Opens Laboratory at the Gladstone Institutes [Gladstone]
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Guided
by colleague and junior faculty member, Christof Fellmann, PhD, the
team will also use CRISPR technology to better understand the genetics
of certain cancers like glioblastoma. Ultimately, they hope to find new
therapeutic targets to probe the genes that these cancers become
dependent upon.
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6.12 Ethique
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6.6 Publications
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Open Access With A Vengeance [In the Pipeline]
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This
has to be the loudest and highest-caliber shot yet across the bow of
the current subscription model in scientific publishing. How will
Elsevier, Springer/Nature, Wiley and the others react? How will the
scientific societies themselves react? That latter question will
emphasize that some of them are, in fact, more publishers than they are
scientific societies, at least as how that latter term is popularly
perceived.
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6.7 DMP, Big Data & applis
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6.7.2 Applis
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6.9 Controverses
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