Onco Actu du 27 août 2018

	1. Biologie
Sequence of events in prostate cancer [Nature] Whole-genome sequencing reveals the duplication of a regulatory region, called an enhancer, of the AR gene in treatment-resistant human prostate cancers. The finding shows the importance of analysing non-protein-coding regions of DNA.
	1.4 Biologie - Technos
No more excuses for non-reproducible methods [Nature] The protocols are dynamic and interactive, rather than static PDFs, so researchers can take notes and track time on smartphones as they perform experiments. When they publish papers, they can get a persistent identifier (in the form of a digital object identifier, or DOI) for their protocol and add it to the methods section.
	2.10 Etiologie - Alcool
The Guardian view on alcohol: drinking less is good for you [The Guardian] But the report’s concentration on the physical ill effects of alcohol consumption leaves two important questions unanswered. The direct physical effects of the drug are not the reasons for its popularity or use. It is the effect on mood and even intellect that many people take it for.
What you need to know about stories proclaiming ‘no safe level of alcohol’ [HealthNewsReview] “There is no safe level of driving, but governments do not recommend that people avoid driving,” Spiegelhalter was quoted saying. “Come to think of it, there is no safe level of living, but nobody would recommend abstention.”
	3.1 Prévention - Tabac
Big Tobacco’s Global Reach on Social Media [NY Times] The tobacco industry says it no longer tries to hook new generations of smokers. So what’s behind the legions of beautiful young people in smoking, vaping and partying posts with the same hashtags?
	3.3 Prévention - Vaccins
The HPV Vaccine: A Critique of a Critique of a Meta-Analysis [Absolutely Maybe Blog] When I first glanced at it, I was shocked and disappointed that Cochrane had seemed to mess up so badly on such an important review. But that flipped the more I dug into it, and it was the critique that increasingly shocked me.
	4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
MSKCC to Seek CDx Status From FDA for Markers on Cancer NGS Panel [Genome Web] Memorial Sloan Kettering Cancer Center is pursuing national Medicare coverage for its MSK-IMPACT next-generation sequencing cancer profiling test by filing with the US Food and Drug Administration to garner companion diagnostic status for at least one marker on the multi-gene panel.
	4.11 Dép., diag. & prono. - Ovaire
Unconscious bias plays role in ovarian cancer screenings [UW Medicine] In patient referrals, primary care physicians are influenced by their own connections to the disease, study suggests.
	5.12.6 Immunothérapies - AMM
Novartis's Kymriah wins EU approval for blood cancer treatment [Reuters] Novartis said it is investing 90 million Swiss francs ($90.39 million) in a new Swiss facility to produce cell and gene therapies, and expects to deliver Kymriah from the site to European patients by the start of 2020.
Novartis receives European Commission approval of its CAR-T cell therapy, Kymriah® (tisagenlecleucel) [Novartis] Novartis is the only company with an approved CAR-T cell therapy for pediatric r/r B-cell ALL and the first to receive approval in two distinct indications, both in the EU and the US.
	5.3 Traitements - FDA, EMA, NICE...
When Medical Innovation Meets Politics [Wall Street Journal] FDA Commissioner Scott Gottlieb on the promise and challenges of biologic drugs, capital risk and ‘regulatory arbitrage’ of generics.
	6. Lutte contre les cancers
For people with cancer, John McCain was a leader to the end [STAT] During surgery, for which I was awake, I decided with my neurosurgeon not to have doctors aggressively remove the tumor, which would damage the surrounding healthy tissue and carried a risk of paralysis. Instead, I opted to leave some of the tumor in my brain, in the margins of the surgical cavity.
AACR Mourns the Loss of Senator John McCain [AACR] Glioblastoma multiforme is an extremely aggressive form of brain cancer that also took the lives of former Vice President Joe Biden's son Beau in May 2015, and Senator Ted Kennedy in August 2009.
John McCain has died. For brain cancers like his, ‘research is our only hope’ [STAT] Instead of out-of-the-box thinking, she said, most research on glioblastoma focuses “on genes we know, pathways we think we know, and drugs that have worked in other cancers. What’s out there and what’s on the [research] agenda is very underwhelming.”
Glioblastoma Advocates Praise John McCain And His Family For Raising Cancer’s Profile [Huffington Post] Dr. Susan Chang, director of the division of neuro-oncology at the University of California, San Francisco, said that when someone in the national spotlight is forthcoming about the challenges they face with a glioblastoma, it can raise awareness of the dire need for more scientific research in this area.
	6.1 Observation
NHS urgent cancer referral targets missed for first time [The Telegraph] NHS targets state that 93 per cent of cases should be seen within a fortnight, so that tests and treatment can be started. But analysis reveals this target was missed for the whole quarter ending June 2018, with the worst performance since records began in 2008.