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1. Biologie
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4.10 Dép., diag. & prono. - Poumon
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4.2 Dép., diag. & prono. - Génome
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4.3 Dép., diag. & prono. - Industriels
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5.10 Traitements - Essais
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Otsuka’s guadecitabine fails phase 3 AML trial [FierceBiotech]
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Guadecitabine’s
failure against the coprimary endpoints eliminates the near-term
prospect of the DNA hypomethylating agent coming to market as a
treatment for elderly AML patients. However, the setback leaves scope
for guadecitabine to advance in other patient populations, either as a
single agent or in combination with chemotherapy or immunotherapy.
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5.12 Immunothérapies
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Turning Off Protein Could Boost Immunotherapy Effectiveness on Cancer Tumors [Johns Hopkins]
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Fan
Pan, M.D., Ph.D., senior author of the study and associate professor of
cancer immunology, said blocking YAP or the signaling pathways under
its control boosted the effects of both a tumor vaccine and a checkpoint
inhibitor (anti-PD1 antibody) to produce even stronger antitumor
activity. He said the approach of therapeutically targeting YAP was
effective over a broad scope of cancer types in mice.
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5.12.3 Immunothérapies-combinaisons
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5.12.5 Immunothérapies - Pharma
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5.12.6 Immunothérapies - AMM
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5.2 Pharma
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5.2.3 Pharma - économie
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5.3.4 Traitements - AMM (FDA, EMA,...)
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6.1 Observation
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Aggressive Prostate Cancer Subtype More Common Than Expected [NCI]
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Nearly
one-fifth of men with metastatic prostate cancer whose tumors were
resistant to hormone therapy subsequently developed an aggressive
prostate cancer subtype, a new study has shown. Men with this subtype,
called treatment-emergent small-cell neuroendocrine prostate cancer
(t-SCNC), appear to have shorter survival than men with other subtypes.
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6.4 Médico-éco
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The NHS' radiotherapy offering badly needs an update [The Telgraph]
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Only
£350 million – five per cent of the NHS' cancer budget – is spent on
radiotherapy. This is considerably lower than the nine per cent budget
for Australia and the European average of 11 per cent. Set this against
the £160 million budget for herceptin, which is a breast cancer drug
used to treat 15-20 per cent of patients.
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6.5 Médecines alternatives
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Cowabunga! Can Cow Therapy Cure Cancer? [Science-Based Medicine]
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A
hospital in India offers to cure cancer in 11 days with Ayurveda and
cow therapy, giving patients a drink of desi cow milk, yogurt, ghee,
urine, and dung. It’s very unlikely that cow therapy can cure cancer;
but in another sense, the author of the book Holy Cancer says it
“healed” him.
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