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1. Biologie
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Teamwork between cells fuels aggressive childhood brain tumour [Institute of Cancer Research]
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In
this study, researchers saw one type of cell leaving the original DIPG
(diffuse intrinsic pontine glioma) tumour site and migrating into the
rest of the brain. This happens early in the evolution of the disease
and is a cell type found in relatively small numbers. As it migrates,
the cells release a chemical messenger called CXCL2, which has the
effect of calling other cells from the tumour to follow it.
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4. Dépistage, diagnostic et pronostic
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4.12 Biopsies liquides
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Study: Blood Test for Prostate Cancer Can Guide Therapy, Extend Lives [Xconomy]
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As
the study authors note, there are two main caveats. First, the survival
data were not statistically significant, perhaps because of the small
sample size; in other words, there’s higher probability they were due to
chance, with p values of .25 for the AR-V7-positive patients and .05
for the AR-V7 negative patients. Second, the study was done
retrospectively.
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4.2 Dép., diag. & prono. - Génome
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5.1 Traitements - Pré-clinique
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Computer Algorithm Maps Cancer Resistance to Drugs, Therapy [Johns Hopkins]
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The
Coordinate Gene Activity in Pattern Sets algorithm (CoGAPS) was used to
determine the molecular changes associated with resistance during the
course of the development of the resistance. It required developing new
methods of collecting data from in vitro cell models and developing a
computational analysis approach to measure these observations that has
not previously been done for cancer.
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5.12 Immunothérapies
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Drug gets body cells to 'eat and destroy' cancer [BBC News]
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The
treatment boosts the action of white blood cells, called macrophages,
that the immune system uses to gobble up unwanted invaders. Tests in
mice showed the therapy worked for aggressive breast and skin tumours,
Nature Biomedical Engineering journal reports.
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5.12.3 Immunothérapies-combinaisons
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5.12.5 Immunothérapies - Pharma
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5.4 Traitements - Economie
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6.1 Observation
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6.10.1 Politiques (USA)
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6.5 Médecines alternatives
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6.6 Publications
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6.7 DMP, Big Data & applis
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6.7.1 IA/bioinformatique
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6.9 Controverses
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