Onco Actu du 25 juillet 2018

	1. Biologie
You Don’t Understand Long Noncoding RNAs [In the Pipeline] There’s an absolute firehose of literature on possible connections to cardiovascular disease, various tumor types, CNS conditions, developmental pathways of all kinds, and pretty much everything else you can think of. That’s what having no well-defined mechanism will do for you – lncRNAs are a blank screen on which you can draw most anything.
	3.3 Prévention - Vaccins
U.K. to offer Merck's Gardasil to boys after years of protests [FiercePharma] Meanwhile, Merck recently reported a shortage of Gardasil 9 doses for private clinics. The company maintained that stocks of its vaccine for the public campaign—Gardasil—remain strong.
Teenage boys to be vaccinated against cancer-causing HPV [The Guardian] The Department of Health and Social Care said England would become one of a small number of countries to offer the vaccination for both girls and boys. The Scottish and Welsh administrations committed last week to expand HPV inoculations to boys.
HPV vaccine to be given to boys in England [Gov.UK] Boys aged between 12 and 13 in England will be given a vaccine to protect them against HPV-related cancers, Public Health Minister Steve Brine has announced today.
HPV jab will be given to boys, government says [BBC News] The policy decision brings England into line with Scotland and Wales.
	3.8 Prévention - Alimentation
Cauliflower, Kale and Carrots May Lower Breast Cancer Risk [NY Times] Researchers used well-validated nutrition questionnaires to examine the association of diet with the risk of invasive breast cancer in 182,145 women. They followed them with periodic examinations for an average of 24 years, during which there were 10,911 cases of invasive breast cancer.
	4. Dépistage, diagnostic et pronostic
Breath test could diagnose pancreatic cancer at an earlier stage [Imperial College London] Researchers took breath samples of 132 patients between March-December 2016. Of these, 57 had cancer and 75 had other benign diseases and pancreatic conditions. To take the test, patients breathed into a device and the volatile compounds in their exhaled breath were analysed at the Division of Surgery’s breath analysis laboratory at St Mary’s Hospital.
	4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
FDA approves magnetic device system for guiding sentinel lymph node biopsies in certain patients with breast cancer [FDA] The Magtrace and Sentimag Magnetic Localization System (Sentimag System) uses magnetic detection during sentinel lymph node biopsy procedures to identify specific lymph nodes, known as sentinel lymph nodes, for surgical removal.
	5.10 Traitements - Essais
NIH expands program that conducts large-scale clinical trials in real-world settings [NIH] The ongoing trials focus on many different diseases, including colon cancer, chronic pain, kidney failure, hospital-acquired infections, suicide prevention, and multiple chronic medical conditions.
	5.12 Immunothérapies
Molecular Characterisation of Clinical Responses to Anti-PD-1 Therapy in Metastatic Gastric Cancer [ESMO] The results point to biomarkers potentially relevant for the selection of patients who may derive greater benefit from PD-1 inhibition.
	5.12.1 Immunothérapies - partenariats
Bristol-Myers Squibb and Tsinghua University Announce Collaboration to Accelerate Early Research into Potential Therapies for Autoimmune Diseases and Cancer [BMS] The collaboration is an expansion of an existing relationship between Bristol-Myers Squibb and Tsinghua University that began in 2012.
Bristol-Myers Squibb, Tsinghua University pen drug discovery pact [FierceBiotech] Researchers at Tsinghua will work to discover and validate drugs against novel targets in cancer and autoimmune diseases. As the programs progress, Bristol-Myers will have the exclusive option to pick up the rights to them.
	5.12.2 Immunothérapies - CAR-T, thérapies cellulaires
GSK and Adaptimmune complete transition of NY-ESO SPEAR T-cell therapy programme to GSK [GSK] GSK ‘794 is an engineered T-cell therapy, for which a patient’s own cells have been genetically modified to express a T-cell receptor (TCR) recognising with high affinity the tumour-specific antigen, NY-ESO.
	5.2 Pharma
Can Celgene's latest Revlimid win reverse the company's bad-news streak? [FiercePharma] While it’ll be tough to judge just how much money a new indication could bring until details on the clinical benefit are available, Leerink Partners analyst Geoffrey Porges said, the positive result “emphasizes the optionality that exists in many parts of the company’s pipeline.”
Glaxo’s New Research Chief Loves Big Pharma. Now He Has To Fix It [Forbes] “We think this is the beginning of a new era in understanding how the immune system becomes dysfunctional, and how disease results from that,” Barron says. He doesn’t mean only cancer or rheumatoid arthritis, but just about any disease.
	6.1 Observation
Patients with Right-Sided Colon Cancer Have Poorer Survival Rates than Those with Left-Sided Disease [American College of Surgeons] Surgeons report that patients with tumors on the right side may benefit from greater lymph node harvest during their operations.
Fertility treatment doesn't boost overall risk of breast, ovary or uterus cancers [Reuters] Although women who undergo fertility treatments do face a small increased risk of noninvasive breast cancer and ovarian tumors, it’s more likely due to other predisposing factors, the study authors wrote in the medical journal BMJ.
	6.7 DMP, Big Data & applis
NIH makes STRIDES to accelerate discoveries in the cloud [NIH] The STRIDES (Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability) Initiative launches with Google Cloud as its first industry partner and aims to reduce economic and technological barriers to accessing and computing on large biomedical data sets to accelerate biomedical advances.