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1. Biologie
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1.1 Biologie - Gènes
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A Close Look at a Cancer Genome [In the Pipeline]
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Note
that in these cells HER2 has been translocated into chromosome 8 from
its original home on chromosome 17 and then copied “dozens of times”
with more translocations. We’re seeing the result of a long series of
bad events piled up on each other. To paraphrase Adam Smith, there is a
lot of ruin in a cell.
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1.4 Biologie - Technos
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2. Etiologie
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2.4 Etiologie - Portables, ondes e-m
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2.6 Etiologie - Environnement
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The man who haunts Europe’s food safety watchdog [Politico]
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“EFSA
respects the right of any individual to express his or her personal
views regarding its scientific conclusions,” the spokesperson said. “We
also believe that for the sake of transparency any relevant interest
should be declared when expressing a view or initiating a campaign,
something that Professor Portier admittedly failed to do when signing
this letter.”
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3. Prévention
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3.3 Prévention - Vaccins
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HPV vaccination for males: effective and safe [BMC Blog]
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Research
has proven the benefits of vaccinating girls against HPV prior to
sexual debut. But could the vaccine also benefit boys? The authors of a
new article published in BMC Medicine conducted a systematic review to
find out. Their results have caused reverberations in the medical
community, already prompting one major European country to update its
vaccination recommendations.
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3.8 Prévention - Alimentation
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Low- or no-calorie soft drinks linked to improved outcomes in colon cancer [Yale News]
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“Artificially
sweetened drinks have a checkered reputation in the public because of
purported health risks that have never really been documented,” said the
study’s senior author, Charles S. Fuchs, M.D., director of Yale Cancer
Center. “Our study clearly shows they help avoid cancer recurrence and
death in patients who have been treated for advanced colon cancer, and
that is an exciting finding.”
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Diet soda and colon cancer: What you need to know [HealthNewsReview]
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This
is an observational study suggesting that colon cancer patients who
regularly drink diet soda have a lower risk of their tumors coming back,
or of dying from their cancer. With this type of study it’s inaccurate
and misleading to imply this is a cause-and-effect relationship.
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4.12 Biopsies liquides
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Liquid Biopsy Controversy Rages On [Forbes]
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More
comprehensive studies with larger numbers of patients, building on the
original study from Johns Hopkins are certainly warranted to ensure
these liquid biopsies are standing up to scrutiny. However, perhaps more
importantly, the subjective nature of interpreting these tests is
simply not compatible with the current marketing approach.
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A Blood Test For Early Detection Of Melanoma? Not Yet [Dr. Len]
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The
research is far from being shown to have proven value in the early
diagnosis of melanoma, a less common but certainly potentially deadly
form of skin cancer. I am not certain the various media headlines and
articles appropriately reflected that fact, once again offering hype
over inconvenient reality.
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4.2 Dép., diag. & prono. - Génome
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4.9 Dép., diag. & prono. - Sein
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No screening is better for women with low breast cancer risk, finds study [The Guardian]
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In
the risk-stratified group, among those who were not screened, there
were 27% fewer over-diagnoses, 3% fewer breast cancer deaths avoided,
and the NHS cost was reduced by £20,000. In the high risk 70%, there
were 71% fewer over-diagnoses, 10% fewer breast cancer deaths avoided,
and the NHS cost was £538,000 less.
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5. Traitements
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5.1 Traitements - Pré-clinique
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5.12 Immunothérapies
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5.12.1 Immunothérapies - partenariats
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5.12.2 Immunothérapies - CAR-T, thérapies cellulaires
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5.12.3 Immunothérapies-combinaisons
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5.12.5 Immunothérapies - Pharma
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Roche takes Tecentriq hit on survival data [Reuters]
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In
contrast, Merck’s Keynote-189 study demonstrated its Keytruda plus
chemotherapy improved survival in newly-diagnosed patients. That leaves
Tecentriq, with sales just a fraction of Keytruda’s and Bristol-Myers
Squibb’s Opdivo, an also-ran in the battle for supremacy against lung
cancer, the disease’s most-lucrative market.
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5.12.6 Immunothérapies - AMM
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5.12.8 Immunothérapies - Economie
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5.2 Pharma
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5.2.1 Pharma - Partenariats
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5.3 Traitements - FDA, EMA, NICE...
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5.3.4 Traitements - AMM (FDA, EMA,...)
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FDA approves ivosidenib for relapsed or refractory acute myeloid leukemia [FDA]
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Approval
was based on an open-label, single-arm, multicenter clinical trial
(AG120-C-001, NCT02074839) that included 174 adult patients with
relapsed or refractory AML with an IDH1 mutation confirmed using the
Abbott RealTime IDH1 Assay, the FDA-approved test for selection of
patients with AML for treatment with ivosidenib.
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5.4 Traitements - Economie
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6. Lutte contre les cancers
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6.1 Observation
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Toward the control of cancer [CA: A Cancer Journal for Clinicians]
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These
articles summarize where we have come from, the current state of cancer
in the United States, and how more consistent and equitable application
of currently available interventions can further reduce the cancer
incidence and death rates. When there are sufficient data to make a
projection, estimates of the potential effect of cancer control
interventions are included.
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6.10 Politiques
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6.10.1 Politiques (USA)
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6.12 Ethique
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6.3 Associations/Fondations
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Biomedical charity places major bet on ‘bold’ research to win bigger payoffs [Science]
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The
London-based Wellcome Trust, announced this week that it would put
£250 million (about $330 million) toward pursuing “bold ideas that would
fall outside the remit of conventional life sciences funding.” The
money is earmarked for ideas that have a high risk of failing or “need
to overcome a major scientific or technical hurdle.” The money will also
be open to researchers without a background in life sciences.
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6.5 Médecines alternatives
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6.6 Publications
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6.7.2 Applis
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Mobile Health Apps Get An FDA Push [Fortune]
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And
while there are clearly some issues that need more creative thinking
and resolution—notably, cybersecurity—the FDA does seem to be creating a
regulatory framework that will encourage progress in digital health,
not quash it.
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6.9 Controverses
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