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1. Biologie
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3.4 Chimioprévention
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3.8 Prévention - Alimentation
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4. Dépistage, diagnostic et pronostic
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5.1 Traitements - Pré-clinique
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Why Not Target DNA? Well. . . [In the Pipeline]
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Can
you get a strong beneficial follow-through by binding to DNA? Who
knows? We honestly don’t understand transcription that well – it’s
wildly complicated, as it would have to be given the three-dimensional
nature of the problem, the number of human genes, and the widely varying
requirements for them to be transcribed.
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5.10 Traitements - Essais
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Altering Chemotherapy Improves Outcomes in Early-Stage Pancreatic Cancer [NCI]
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Together,
the two trials immediately raise additional questions, Dr. Rudloff
said. They include whether mFOLFIRINOX should replace gemcitabine as
neoadjuvant therapy and whether using newer types of radiation therapy,
such as stereotactic body radiation therapy, in neoadjuvant treatment
regimens could further improve outcomes.
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Metastasis-free Survival — A New End Point in Prostate Cancer Trials [NEJM]
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The
FDA has now recognized that a prolonged delay in development of
metastatic disease is an objective and clinically relevant measure.
Future agents may be approved on the basis of metastasis-free survival
only if substantial effects on this transition are demonstrated and the
safety profile is acceptable for a medication taken long-term.
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5.12 Immunothérapies
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5.2 Pharma
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5.2.3 Pharma - économie
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5.3 Traitements - FDA, EMA, NICE...
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FDA Details Hiring Challenges [Biocentury]
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FDA
medical officers earn 46% below salaries they could earn in the private
sector. Among other positions, mathematical statisticians earn 41%
less, pharmacists 35%, chemists 33%, and toxicologists 26%.
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5.4 Traitements - Economie
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6.1 Observation
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