jeudi 28 juin 2018

Onco Actu du 28 juin 2018

1. Biologie

Using the principles of evolution to treat and prevent cancer [STAT]

2. Etiologie

Cancer-causing virus HTLV-1 changes DNA loops, affecting thousands of genes [imperial College]

4.12 Biopsies liquides

Artificial Intelligence to Boost Liquid Biopsies [The Scientist]

5. Traitements

What Can Cancer Specialists Learn From Patients Who Beat All The Odds? [NPR]

5.10 Traitements - Essais

With Lynparza's first-line ovarian cancer win, AstraZeneca and Merck get a shot at $1B sales boost [FiercePharma]

AstraZeneca’s PARP Drug Is First to Help New Ovarian Cancer Patients [Xconomy]

Clinical trial success for AstraZeneca's key ovarian cancer drug [The Telegraph]

5.12.2 Immunothérapies - CAR-T, thérapies cellulaires

AbbVie powers CAR-macrophage startup Carisma to $53M A round [FierceBiotech]

5.2 Pharma

U.S. FDA Grants Priority Review for Pfizer’s New Drug Application for Glasdegib in Patients with Previously Untreated Acute Myeloid Leukemia [Pfizer]

5.2.1 Pharma - Partenariats

AbbVie and Calico Announce Extension of Groundbreaking Collaboration [AbbVie]

5.3.4 Traitements - AMM (FDA, EMA,...)

Ready to challenge Novartis and Roche, Array scores FDA nod for melanoma combo [FiercePharma]

Array wrestles FDA OK for its MEK/BRAF melanoma combo, to hit the pharmacy as Mektovi and Braftovi [EndPoints]

Array Biopharma Announces FDA Approval Of Braftovi™ (Encorafenib) In Combination With Mektovi® (Binimetinib) [Array Biopharma]

Array BioPharma gets FDA nod for melanoma combo treatment [Reuters]

6.1 Observation

NIH study associates obesity with lower breast cancer risk in young women [NIH]

6.6 Publications

Retracted papers keep being cited as if they weren’t retracted. Two researchers suggest how Elsevier could help fix that. [Retraction Watch]

2017 Journal Impact Factors Feature Citation Distributions [The Scholarly Kitchen]

6.7 DMP, Big Data & applis

The Topol Review [NHS]

6.9 Controverses

Personalised cancer medicine: What’s the evidence it works? [Cancer World]