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1. Biologie
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Researchers discover new type of lung cancer [Cold Spring Harbor Lab]
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Using
this “CRISPR screen,” the team found that a transcription factor called
POU2F3 is expressed exclusively in the minority of SCLC tumors with low
levels of neuroendocrine markers. It turns out that this variant form
of SCLC tumors are derived from a separate class of rare cells called
tuft cells.
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2.6 Etiologie - Environnement
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Flight attendants may have higher cancer rates [Reuters]
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Researchers
asked 5,366 flight attendants and 2,729 other adults with similar
socioeconomic backgrounds whether they had ever been diagnosed with
cancer. Compared to the other adults, flight attendants were 51 percent
more likely to develop breast cancer. They also had more than double the
risk of melanoma and more than quadruple the odds of being diagnosed
with other forms of skin cancer.
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3. Prévention
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3.2 Prévention - Obésité
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4.12 Biopsies liquides
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4.5 Dép., diag. & prono. - Colorectal
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5. Traitements
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5.10 Traitements - Essais
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5.12.2 Immunothérapies - CAR-T, thérapies cellulaires
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5.12.3 Immunothérapies-combinaisons
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5.12.4 Immunothérapies - Essais
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With Roche Data, Cancer Combos Post First Win Vs. Small Cell Lung Cancer [Xconomy]
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There
are no approved immunotherapies yet for SCLC, a fast moving lung cancer
that accounts for about 10 to 15 percent of cases, according to the
ACS. Carboplatin/etoposide chemotherapy has remained the standard of
care for years, and other immunotherapy regimens, like a Bristol
combination of ipilimumab (Yervoy) and chemo, have previously failed.
Things could soon change, however.
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5.12.5 Immunothérapies - Pharma
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5.2 Pharma
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5.3 Traitements - FDA, EMA, NICE...
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6.1 Observation
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Some adult survivors of childhood cancer unconcerned about health [Reuters]
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In
a survey of 15,620 adult survivors of childhood cancer and 3,991 of
their siblings, 31 percent of the cancer survivors and 34 percent of
their siblings said they weren’t worried about their health. And 40
percent of the survivors weren’t concerned about developing cancer
again, similar to the proportion of their siblings who didn’t worry
about future malignancies.
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6.10.1 Politiques (USA)
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6.11 Patients
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6.5 Médecines alternatives
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Clínica 0-19: False hope in Monterrey for brain cancer patients [Science-Based Medicine]
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Unfortunately,
their treatment is an unproven combination of 11 chemotherapy drugs
injected into an artery feeding the brainstem, plus an unknown and
unproven “immunotherapy.” Of course it all costs $300,000 or more for a
complete course of treatment, and the good doctors are “too busy to do
clinical trials” or even publish their survival and recurrence
statistics, despite having used this protocol for 20 years.
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