vendredi 1 juin 2018

Onco Actu du 1er juin 2018

2.5 Etiologie - Gènes

Fifty years since DNA repair was linked to cancer [Nature]

3.1.1 Prévention - Tabac - e-cigs

World No Tobacco Day: Q&A with Mathieu Morissette and Riccardo Polosa [BMC Blogs]

4. Dépistage, diagnostic et pronostic

Organoid profiling personalizes treatments for pancreatic cancer [Cold Spring Harbor Lab]

4.5 Dép., diag. & prono. - Colorectal

Infection Rates After Colonoscopy, Endoscopy at US Specialty Centers Are Far Higher Than Previously Thought [Johns Hopkins]

Many journalists fail to question new Cancer Society colorectal cancer screening guidelines [HealthNewsReview]

5. Traitements

Drugs OK’d To Hit Tumor Genes Still a Basket of One. Are More Coming? [Xconomy]

5.1 Traitements - Pré-clinique

Antifungal drug eliminates sleeping bowel cancer cells in mice [Cancer Research UK]

5.10 Traitements - Essais

Utilizing Patient-reported Outcomes in Cancer Clinical Trials [Cancer Research Analyst]

New Treatment Approach Could Help Prevent Recurrences of Some Bladder Cancers [NCI]

5.12 Immunothérapies

IDO Don’ts: After Immunotherapy Failure, Experts Say Slow Down [Xconomy]

5.12.1 Immunothérapies - partenariats

Despite ASCO wobble, Syndax pals up with Nektar on entinostat combo trial [FierceBiotech]

Syndax and Nektar Therapeutics Announce Immuno-Oncology Clinical Trial Collaboration [Syndax]

5.12.2 Immunothérapies - CAR-T

FDA-Approved CAR T-Cell Therapy in WNY [Roswell Park]

TxCell names Lonza as its CAR-Treg cellular product manufacturer [TxCell]

Tumour tamed by transfer of one T cell [Nature]

5.4 Traitements - Economie

Trump says drugmakers plan to offer 'massive drops' in prices—fact or fantasy? [FiercePharma]

Pfizer's Xalkori makes it onto Cancer Drugs Fund [PharmaTimes]

Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer [NICE]

Leading oncology group wary of Trump drug price proposals [Reuters]

Pill to treat ovarian cancer approved for use on NHS [The Guardian] ASCO (général) - Académiques

ASCO 2018: World’s largest cancer conference seeks to expand the reach of precision medicine [Institute of Cancer Research]

5.5.10 ASCO (hémato)

ASCO Preview: Lymphoma Presentation Highlights [Cancer Network]

5.5.15 ASCO (biopsies liquides)

Doctors welcome possible 'holy grail of cancer research' [The Guardian]

5.5.16 ASCO (médecine de précision)

Beyond BRCA: Examining Links between Breast Cancer, Second Primary Cancer and Inherited Genetic Mutations [Penn Medicine]

5.9.3 EHA

AbbVie to Present New Data from Several Investigational Studies of Venetoclax as Monotherapy or in Combination for the Management of a Number of Difficult-to-Treat Blood Cancers at 23rd European Hematology Association (EHA) Annual Congress [AbbVie]

6.10 Politiques

After Brexit, can British science have its cake and eat it, too? [Nature]

6.10.1 Politiques (USA)

FDA Prepares to Implement ‘Right-to-Try’ Law [RAPS]

‘Right-to-try’ law intended to weaken the FDA, measure’s sponsor says in blunt remarks [STAT]

6.6 Publications

Collect & Connect - Improved and Updated! [ORCID]

6.7 DMP, Big Data & applis

When Scientists Develop Products From Personal Medical Data, Who Gets To Profit? [NPR]

Resolving the Productivity Paradox of Health Information Technology [JAMA]

Big Data and Predictive Analytics - Recalibrating Expectations [JAMA]

6.9 Controverses

Who gets credit for CRISPR? Prestigious award singles out three, and leaves out a notable scientist [STAT]

Elizabeth Holmes' Superpower [Forbes]