Onco Actu du 29 mai 2018

	1. Biologie
Learning from a cancer’s past could predict its future [Cancer Research UK] “We haven’t invented new maths,” says co-leading author Dr Andrea Sottoriva, a Cancer Research UK Fellow from the Institute of Cancer Research, London. “We’ve taken what others have built over the past few decades to study various populations, and applied this maths to cancer.”
Maybe DNA Can’t Answer All Our Questions About Heredity [Wired] Carl Zimmer's new book _She Has Her Mother’s Laugh_ is a book about the question genetics was invented to answer—and perhaps can't.
	3.1 Prévention - Tabac
One million French smokers quit in a year amid anti-smoking measures [BBC News] Such a drop has not been seen in a decade, according to Public Health France, which carried out the study.
	4. Dépistage, diagnostic et pronostic
CDC announces review of pre-op diagnosis of uterine cancers by gynecologists [The Cancer Letter] These new estimates could mean that about 8,640 women annually are at risk of having their undetected uterine cancers upstaged—especially if their gynecologists fail to preoperatively diagnose the malignancies and proceed to use surgical procedures that fragment the tissue or that do not otherwise follow oncologically safe principles.
Noorchashm: Uterine cancers are not “occult” if gynecologists don’t bother to look [The Cancer Letter] So it’s a serious professional misrepresentation for any gynecologist to describe the cancers quantified by the Yale group as being “occult”, when they are in truth “missed” because of the laxity in preoperative tissue diagnosis standards in gynecology.
	4.13 Dép., diag. & prono. - Peau
Computer learns to detect skin cancer more accurately than doctors [The Guardian] Artificial intelligence machine found 95% of melanomas in study compared to 86.6% for dermatologists.
	5.10 Traitements - Essais
How to avoid common problems when using ClinicalTrials.gov in research: 10 issues to consider [BMJ] Conducting valid analyses requires an understanding of both the capabilities and limitations of the database (that is, intrinsic factors) as well as reporting policies and other factors external to the database that influence the types of studies in ClinicalTrials.gov in a specified time.
	5.12 Immunothérapies
Patients with mUC and Low PD-L1 Expression May Have Decreased Survival When Treated with Pembrolizumab or Atezolizumab [ESMO] The FDA safety alert considers treatment of patients with metastatic urothelial cancer who have not received prior therapy.
	5.12.2 Immunothérapies - CAR-T
Study Identifies New Way to Combat a Serious CAR T Cell Therapy Side Effect [Memorial Sloan Kettering Cancer Center] Researchers at the Sloan Kettering Institute have identified the cause of a serious immunotherapy side effect as well as ways to stop or prevent it. The study on cytokine release syndrome was done in mice but the approach will soon be tested in people.
	5.12.5 Immunothérapies - Pharma
Roche's Tecentriq meets targets in lung cancer trial [Reuters] Roche has eight Phase III lung cancer studies underway evaluating Tecentriq alone or in combination with other medicines.
Phase III IMpower130 study showed Roche’s Tecentriq (atezolizumab) plus chemotherapy (carboplatin and Abraxane) helped people with metastatic non-squamous NSCLC live significantly longer compared to chemotherapy alone [Roche] These data will be presented at an upcoming oncology congress.
	5.2.3 Pharma - économie
EU makes it easier for companies to produce generic medicines for export [Reuters] While these rules were introduced to aid research investments, it appeared that companies were also shifting production of generics for export out of Europe as a result, the Commission said.
	6.7.1 IA/bioinformatique
IBM's Watson Health wing left looking poorly after 'massive' layoffs [The Register] "They are laying off 50 to 70 per cent of staff. Not sure about total affected since there's no transparency, but our Dallas office has 230 people."
	6.7.2 Applis
Opinion: How to Use Mobile Apps for Immunohistochemistry [The Scientist] This guide for apps comes from personal experience testing various programs aimed to improve productivity or to help with selecting reagents.