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2.5 Etiologie - Gènes
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Gene mapping: More Monty Python than Monty Python [The Mermaid's Tale]
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So,
if biological causation is complex, as these studies and diverse other
sorts of direct and indirect evidence clearly show, then why can't we
pull the plug on these sorts of studies, and instead, invest in some
other mode of thinking, some way to do focused studies where genetic
causation is clear and real, rather than continuing to feed the welfare
state of GWAS?
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2.6 Etiologie - Environnement
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Some Thoughts on Exposure to the World Trade Center Wreckage and Cancer [JAMA Oncology]
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They
report that WTC-exposure may be a risk factor for the development of
multiple myeloma and its precursor disease, MGUS. This is appropriately
worded. The operative word is “may.” These trials, because of the size
of cohort, cannot identify a small increase in cancer risk due to WTC
exposure, and correlation does not mean causation. Perhaps this issue is
beyond the limits of science.
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4. Dépistage, diagnostic et pronostic
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4.12 Biopsies liquides
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Noninvasive brain tumor biopsy on the horizon [Washington University in St. Louis]
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Once
they had the target — in this case, the brain tumor — researchers then
injected microbubbles that travel through the blood similar to red blood
cells. When the microbubbles reached the target, they popped, causing
tiny ruptures of the blood-brain barrier that allows the biomarkers from
the brain tumor to pass through the barrier and release into the
bloodstream.
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4.2 Dép., diag. & prono. - Génome
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Francis Collins, NIH Director, Answers Reddit’s Genomics Questions [NIH]
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"If
you were diagnosed with cancer today, you would want to be sure that
your cancer was subjected to genome sequencing to identify what pathways
are causing those cells to become malignant. You would then want to use
that information to choose the right course of treatment for your
particular cancer, not some one-size-fits-all approach."
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5.10 Traitements - Essais
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5.12 Immunothérapies
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5.12.2 Immunothérapies - CAR-T
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CAR-T 2.0? A split, universal and programmable system [FierceBiotech]
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"Our
most immediate work is to figure out what type of cancer would really
benefit from this type of combinatorial targeting and control," Wong
said. This could include cancers with a lot of heterogeneity that don't
have a single good marker, he said. The rest will be a major engineering
challenge, he added. "Every cancer is probably going to need some
fine-tuning in the adaptor molecule."
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NHS preparing to offer ‘game-changing’ cancer treatment [The Guardian]
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“The
process of genetically altering a patient’s own immune cells is
immensely complex and also very expensive. We hope that manufacturers
can agree on a deal that ensures affordable access for patients in the
UK as soon as possible, to achieve long-term remissions and even cures.”
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The Million-Dollar Cancer Treatment: Who Will Pay? [Wall Street Journal]
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But
the price of the drugs is just the beginning, hospitals and insurers
say. Administering these therapies can add hundreds of thousands of
dollars to the tab, including lengthy hospital stays and use of other
services and medicines. It isn’t clear how much hospitals will get paid
for these new treatments.
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5.12.3 Immunothérapies-combinaisons
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5.12.5 Immunothérapies - Pharma
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5.3 Traitements - FDA, EMA, NICE...
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5.4 Traitements - Economie
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5.5.1.1 ASCO (général) - Industriels
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6.10 Politiques
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Windrush case: UK to give Albert Thompson indefinite right to remain [The Guardian]
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Thompson
was told he would have to pay £54,000 for the radiotherapy treatment he
needed for prostate cancer because he could not provide officials with
sufficient documentary evidence that he had lived in the UK continuously
since arriving from Jamaica as a teenager in 1973. Despite having tax
and national insurance records going back decades, the 63-year-old had
been struggling to prove he had the right to remain in the UK.
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6.9 Controverses
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