mercredi 18 avril 2018

Onco Actu du 18 avril 2018

1. Biologie

Scientists uncover 80 potential lines of attack against prostate cancer [Institute of Cancer Research]

4.12 Biopsies liquides

QIAGEN launches AdnaTest liquid biopsy kits in prostate and lung cancer [Qiagen]

5. Traitements

Medicine’s secret ingredient — it’s in the timing [Nature]

5.2 Pharma

In light of Incyte’s epacadostat debacle, NewLink scraps PhIII plans for its own IDO drug [EndPoints]

5.2.3 Pharma - économie

4,000,000 Reasons to Back China Biotech [Bloomberg]

J&J raises sales forecast on strong demand for cancer drugs [Reuters]

5.3.4 Traitements - AMM (FDA, EMA,...)

U.S. Food and Drug Administration Approves Opdivo® (nivolumab) + Yervoy® (ipilimumab) Combination as First-Line Treatment for Patients with Intermediate- and Poor-Risk Advanced Renal Cell Carcinoma [BMS]

5.4 Traitements - Economie

James Raftery: A more fundamental review of QALYs is needed [BMJ Blogs]

5.9.12 AACR - biopsies liquides

GRAIL Announces Data from Prototype Blood Tests for Early Cancer Detection [GRAIL]

Blood test shows promise for spotting early cancers [Science]

5.9.3 AACR - mélanome

Cancer Cells Actively Fuel Growth and Metastasis by Reprogramming Healthy Cells, Roswell Park Team Shows [Roswell Park]

Checkmate's I-O combo reverses PD-1 resistance in melanoma patients [FierceBiotech]

TLR9 Agonist CMP-001-Pembrolizumab Combination Shows Early Efficacy in Patients With Metastatic Melanoma Resistant to Anti-PD-1 [AACR]

Combination therapy strengthens T cells in melanoma pre-clinical study [MD Anderson Cancer Center]

5.9.4 AACR - poumon

AACR Annual Meeting 2018: A Round-up of Practice-changing Lung Cancer Immunotherapy Clinical Trials [Cancer Research Catalyst]

Immune Therapy Improves Lung Cancer Patients’ Survival [The Scientist]

Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery [Johns Hopkins]

5.9.7 AACR - divers

Experts Discuss Insights From Molecular Tumor Boards, Clinical NGS Programs at AACR [Genome Web]

An Augmented Reality Microscope for Cancer Detection [Google Research Blog]

Short-acting Calcium Channel Blockers Were Associated With Increased Risk of Pancreatic Cancer in Postmenopausal Women [AACR]

Dual Inhibition of IDO1 and PD-L1 Safe in Patients With Advanced Solid Tumors [AACR]

5.9.9 AACR - immunothérapies

How does leukemia escape from immunotherapy? [Fred Hutch]

In CheckMate -141, Opdivo (nivolumab) Demonstrated Sustained Overall Survival (OS) Advantage over Standard of Care in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) [BMS]

6.1 Observation

It is time to end the post-code lottery for secondary cancer care [The Telegraph]

More activity, healthier diet tied to extended survival after colon cancer [Reuters]

6.11 Patients

Why I dread yet another cancer confessional [The Guardian]