vendredi 13 avril 2018

Onco Actu du 13 avril 2018

1. Biologie

Genetic changes linked to adult kidney cancer can occur in childhood [Wellcome Trust]

Piecing together kidney cancer evolution [Cancer Research UK]

1.1 Biologie - Gènes

St. Jude Cloud, largest public repository of pediatric cancer genomics data, launches for researchers worldwide [St. Jude Children's Research Hospital]

2.10 Etiologie - Alcool

Drinking an extra glass of wine 'will shorten your life by 30 minutes' [The Guardian]

Did Drinking Give Me Breast Cancer? [Mother Jones]

3.1 Prévention - Tabac

EU court adviser says ban on Swedish snuff tobacco product valid [Reuters]

4.10 Dép., diag. & prono. - FDA, EMA, NICE,...

FDA Finalizes NGS Guidances; Proposes Guidance on Investigational IVDs in Cancer Rx Trials [Genome Web]

Next-generation sequencing: FDA offers guidance to streamline path to market [EndPoints]

Leveraging Innovation for the Treatment of Cancer [FDA]

4.2 Dép., diag. & prono. - Génome

Towards access to at least 1 million sequenced genomes in the European Union by 2022 [EAPM]

5. Traitements

Last Month in Oncology with Dr. Bishal Gyawali: March 2018 [ecancernews]

5.1 Traitements - Pré-clinique

Cancer Protein Could Point to New Targets for Treatment [Howard Hughes Medical Institute]

5.10 Traitements - Essais

Dual Targeting of BTK and BCL2 in Mantle-Cell Lymphoma [ESMO]

5.12 Immunothérapies

Pivotal findings from the cancer-immunology nexus [Cross Talk]

5.12.2 Immunothérapies - CAR-T

Can CAR-T and gene therapy cures really sustain biopharma? Not for all, analyst says [FiercePharma]

As gene editing explodes, a new report from Goldman says Chinese groups are seizing the lead on CRISPR and CAR-T studies [EndPoints]

5.12.3 Immunothérapies-combinaisons

Life After ECHO-301: Lessons Learned About Modulating IDO/TDO To Treat Cancer [Life Sci VC]

5.12.4 Immunothérapies - Essais

Roche’s immunotherapy lucky streak ends with deaths in trial [Pharmafile]

5.12.7 Immunothérapies - vaccins

New Ovarian Cancer Vaccine Shows Promise [The Scientist]

A personalized vaccine helps patients fight back against ovarian cancer [LA Times]

5.2.2 Pharma - Fusions & Acquisitions

Pfizer's Deal Potential Doesn't Stop at Bristol-Myers [Bloomberg]

5.2.3 Pharma - économie

Abpro files $69M IPO to take bispecific antibodies into the clinic [FierceBiotech]

5.3 Traitements - FDA, EMA, NICE...

EMA reviewing risk of dosing errors with methotrexate [EMA]

Does the FDA’s ‘breakthrough’ drug program need to be reformed? Harvard skeptics say yes [EndPoints]

5.4 Traitements - Economie

As cancer drug prices climb, value not keeping pace [Reuters]

5.9 AACR

Highlighting Pediatric Preclinical Drug Testing at the Annual Meeting 2018 [Cancer Resarch Catalyst]

Advice from Advocates: How to Navigate the Annual Meeting [AACR]

5.9.8 AACR - Pharma

Seattle Genetics Highlights Novel Antibody-Drug Conjugate Technologies and Immuno-Oncology Program Advances at the American Association for Cancer Research (AACR) Annual Meeting [Seattle Genetics]

6.4 Médico-éco

Payment Bundles That Include Drug Costs May Destabilize Cancer Care Delivery Environment [ASCO]