Onco Actu du 8 février 2018

	2.6 Etiologie - Environnement
WHO rebuts House committee criticisms about glyphosate cancer warning [Science] "IARC defers risk assessment and risk management to national and international bodies, restricting itself to provision of hazard identification as a scientific foundation to those subsequent steps," Wild added.
How Toxic is the World’s Most Popular Herbicide Roundup? [The Scientist] Glyphosate, the active ingredient in Roundup, is designed to be toxic to plants, but scientists observe some untoward effects on animals in the lab.
	3.1.1 Prévention - Tabac - e-cigs
Misconceptions about e-cigarette safety might be stopping smokers using them to quit [Cancer Research UK] The report says that public perception of the safety of e-cigarettes has got worse in recent years, despite building evidence that vaping is less harmful than smoking.
U.S. senators ask FDA to reject Philip Morris' iQOS application [Reuters] An FDA official said on Wednesday the agency had received the letter and would respond directly to the senators.
	3.8 Prévention - Alimentation
Manipulating a mouse’s diet can stop breast cancer spreading [Cancer Research UK] So far the story suggests that lowering asparagine levels blunts the ability of cancer cells to spread in mice, but doesn’t affect the original tumour. The researchers think this could be down to the amount of asparagine that is naturally found in different parts of the body.
Spread of breast cancer linked to compound in asparagus and other foods [The Guardian] “This is a very promising lead and one of the very few instances where there is a scientific rationale for a dietary modification influencing cancer,” said lead scientist Prof Greg Hannon, director of the Cancer Research UK Cancer Institute in Cambridge.
	4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
Pancreatic cancer patients should be offered early scans to avoid unnecessary surgery, says NICE [NICE] The first NICE guideline on the diagnosis and management of pancreatic cancer recommends the use of a different type of computed tomography (CT) scan, called PET-CT. The scan will speed up diagnosis and more accurately determine the stage of pancreatic cancer in patients.
	4.7 Dép., diag. & prono. - Col de l'utérus
More evidence ‘Unfortunate Experiment’ led to cancer – In the News [Science Media Center] Some women who were unknowingly included in the ‘Unfortunate Experiment’ at Auckland’s National Women’s Hospital went on to develop cervical cancer after being diagnosed with microinvasive cancer but not given treatment.
	5.12.2 Immunothérapies - CAR-T
Scotland’s TCB inks CAR-T deal with Japan’s NIPRO [PharmaTimes] The group has signed a strategic collaboration with Osaka, Japan-based The NIPRO Corp to co-develop a novel immunotherapy product using TCB’s safe CAR-T platform, ImmuniCAR, which utilises unique properties of modified gamma-delta T cells to selectively target cancer whilst leaving healthy cells untouched.
Breakthrough cancer therapy raises tough questions about drug costs, value [The Enquirer] “The key question is not: What’s it worth to save a child’s life?” Mitchell said. “If that was the question, then the polio [vaccine] they gave me when I was 6 years old would have cost a million dollars. The right question is: What is the price that will maximize accessibility and affordability, while maintaining a robust R&D pipeline?”
	5.2 Pharma
At Verastem, Infinity’s Former Blood Cancer Drug Heads to FDA [Xconomy] If approved, duvelisib, a pill that blocks PI3 kinases, a well known cancer target, would be Verastem’s first marketed product—a twist of fate considering Verastem started out developing stem cell therapies for cancer and duvelisib has been in the hands of several other drugmakers over the years.
Verastem submits new drug application to U.S. FDA for duvelisib for the treatment of patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma [Verastem] Duvelisib is a first-in-class investigational, dual inhibitor of phosphoinositide 3-kinase (PI3K)-delta and PI3K-gamma, two enzymes known to help support the growth and survival of malignant B-cells and T-cells.
Verastem takes AbbVie’s blood cancer castoff to the FDA [EndPoints] Duvelisib has a nomadic past, traveling from Intellikline, where it was originally discovered, to Infinity in 2010. Then in 2014, AbbVie paid $275 million in an upfront deal to co-develop the drug but was disappointed in the results.
Sanofi sounds taps on a half dozen drug programs in latest pipeline cleanup [EndPoints] Touted as a potential blockbuster for multiple myeloma and a top prospect in their late-stage pipeline, Sanofi is discarding a mid-stage effort on acute lymphoblastic leukemia for the anti-CD38 antibody isatuximab, according to its pipeline update today.
	5.2.3 Pharma - économie
With startup, George Church bets cryptocurrency will boost genome sequencing [STAT] Individuals who “join the Nebula network” can participate in surveys by “data buyers” — pharma or biotech companies developing DNA-based drugs, but also academics studying genetic variants and diseases or other traits.
This new company wants to sequence your genome and let you share it on a blockchain [MIT Technology Review] Obbad says biotech and pharma companies won’t actually be able to download data shared by owners, just borrow it. Data owners will remain anonymous, while buyers will have to be fully transparent about their identity.
	5.4 Traitements - Economie
Patients to benefit from myeloma treatment through CDF deal [NICE] Takeda, who market the drug, struck a deal with NHS England after NICE said ixazomib should be available whilst more evidence is gathered on its value.
NICE Publishes Technology Appraisal Guidance About Intrabeam Radiotherapy System for Adjuvant Treatment of Early Breast Cancer [ESMO] It is not recommended for routine commissioning during breast-conserving surgery.
	5.5.14 ASCO (vessie)
Exelixis Announces Updated Phase 1 Trial Results for Cabozantinib in Combination with Nivolumab with or without Ipilimumab in Refractory Genitourinary (GU) Tumors [Exlixis] These initial results suggest that further evaluation of cabozantinib in combination with nivolumab with or without ipilimumab is warranted for metastatic urothelial carcinoma.
	5.5.3 ASCO (prostate)
Myriad's myRisk® Hereditary Cancer Test Finds More Than 12 Percent of Men with Prostate Cancer Carry an Inherited Genetic Mutation [Myriad] Results from a Large 1,100 Patient Study Will Be Presented at the 2018 Genitourinary Cancer Symposium.
Bayer to showcase latest prostate cancer research at ASCO GU 2018 Cancer Symposium [Bayer] New data on the long-term efficacy and safety of Xofigo® (radium-223 dichloride) / Update on ongoing studies with darolutamide, a novel investigational oral androgen receptor (AR) antagonist, including the ARASENS pivotal trial in men with metastatic hormone-sensitive prostate cancer.
	6. Lutte contre les cancers
SCO Examines the Current Oncology Clinical Pathways Landscape [ASCO] The report found that--with a few exceptions--overall, prominent commercial pathway programs in this country are largely aligned with ASCO's criteria.
The Future of Precision Medicine in Australia [ACOLA] ACOLA’s precision medicine project explores the current trends in precision medicine technologies and explores the role that a broader implementation of precision medicine capabilities may play in the Australian context.
Last Month in Oncology with Dr. Bishal Gyawali: January 2018 [ecancernews] We have known for some time now that RECIST is not a good metric to evaluate response with immunotherapies in cancer. This new study shows that some patients may benefit with continuation of immunotherapies beyond progression, but a better conclusion would be that RECIST is not a good metric for immunotherapy.
	6.1 Observation
Reasons Not To Freak Out About Risk Of Heart Disease After Breast Cancer [Forbes] As I see it, concern about treatment toxicity is all-the-more reason to find breast cancer early. Because the best way to treat invasive breast cancer is to nip it in the bud.
Many breast cancer survivors may die of heart disease, doctors warn [Reuters] “Women have a higher risk for heart disease if they go untreated for existing cardiovascular risk factors or develop risk factors such as obesity or low fitness during breast cancer treatment.”
	6.10 Politiques
Germany's Angela Merkel finally reaches coalition deal with SPD [DW] What's included in the deal? Agriculture : The pesticide glyphosate, a source of much friction between the CSU and SPD , will be banned, along with genetically modified crops.
	6.6 Publications
Let’s move beyond the rhetoric: it’s time to change how we judge research [Nature] DORA’s aim is a world in which the content of a research paper matters more than the impact factor of the journal in which it appears. Thousands of individuals and hundreds of research organizations now agree and have signed up.