vendredi 23 février 2018

Onco Actu du 23 février 2018

1. Biologie

Unprecedented Video Shows How DNA Is Organized in Real Time [Gizmodo]

Molecular Switch Links High-Fat Diet to Prostate Cancer Metastasis [NCI]

2. Etiologie

Cancer Risk Associated With Key Epigenetic Changes Occurring Through Normal Aging Process [Johns Hopkins]

2.5 Etiologie - Gènes

Add broken DNA repair to the list of inherited colorectal cancer risk factors [Broad Institute]

3.1 Prévention - Tabac

Dutch prosecutors say won't open criminal case against big tobacco firms [Reuters]

5.1 Traitements - Pré-clinique

Mini-tumours' created to battle cancer [BBC News]

Lab-grown ‘mini tumours’ could personalise cancer treatment [Cancer Research UK]

5.10 Traitements - Essais

Pressure is on, sponsors. AllTrials to shame delayed clinical trial results reporting [FierceBiotech]

AllTrials puts FDA under pressure with Trials Tracker [Pharmafile]

Cost of Trials [In the Pipeline]

5.12.1 Immunothérapies - partenariats

All in: Gilead maps a $3.15B gene editing alliance with Sangamo for off-the-shelf CAR-T drugs [EndPoints]

Continuing Cell Therapy Push, Gilead Aligns with Sangamo for CAR-T Boost [Xconomy]

Kite, a Gilead Company, and Sangamo Therapeutics Announce Collaboration to Develop Next-Generation Engineered Cell Therapies for the Treatment of Cancer [Business Wire]

Sangamo in $3 billion gene-editing deal with Gilead [Reuters]

5.2 Pharma

Evestra Snags DoD Grant For Experimental Breast Cancer Drug Research [Xconomy]

5.2.1 Pharma - Partenariats

Fred Hutch, UW Medicine alliance with Takeda to advance promising early-stage research [Fred Hutch]

Deal-hungry Takeda forges another R&D alliance [FierceBiotech]

5.4 Traitements - Economie

Do academic organisations make enough money from their inventions? [Institute of Cancer Research]

NICE sticks with ‘no’ for earlier use of Halaven [PharmaTimes]

6. Lutte contre les cancers

Patients to benefit from new brain cancer research funding boost [Cancer Research UK]

6.1 Observation

High Body Fat Level Is Associated With Increased Risk of ER-Positive Breast Cancer in Postmenopausal Women Even With Normal BMI [ESMO]

6.10 Politiques

Bolster European Research Area to boost science post-Brexit [Wellcome Trust]

U.K. scientists increasingly anxious about Brexit confusion [Science]

6.10.1 Politiques (USA)

Trump: New HHS chief has already lowered drug prices [STAT]

6.6 Publications

Q&A: Blazing trails through the Wild West of research metrics [Nature]

6.9 Controverses

Science needs to redefine excellence [Nature]